Database : HANSEN Search on : TOLERANCIA IMUNOLOGICA [Subject descriptor] References found : 14 [refine] Displaying: 1 .. 14   in format [Detailed]

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Id: 13501 Author: Haregewoin, Abebe; Godal, Tore; Mustafa, Abu Salim; Belehu, Ayele; Yemaneberhan, Tabebe Title: T-cell conditioned media reverse T-cell unresponsiveness in lepromatous leprosy ..- Source: s.l; s.n; May 26, 1983. 3 p. . Abstract: In some subjects the infective agent of leprosy, Mycobacterium leprae, causes disseminated (lepromatous) disease. Such subjects have a major role in the transmission of the disease and show deficient T-cell responses both in vivo and in vitro to M. leprae, but not to other antigens. Numerous studies have recently shown that T cells with functional capabilities after initial triggering with antigen can be maintained in a state of continuous proliferation in vitro when cultured in medium containing interleukin 2 (IL-2). Here we have studied the effect of IL-2 rich T-cell conditioned medium on lepromatous peripheral blood mononuclear cells. Our results show that although lepromatous T cells fail to produce IL-2 after exposure to M. leprae they can respond by proliferation to M. leprae in the presence of T-cell conditioned medium, suggesting that the unresponsiveness in lepromatous leprosy results from a deficiency in the production of IL-2 or related factors and not a lack of M. leprae-reactive T cells.(AU). Descriptors: MEIOS DE CULTURA TOLERÂNCIA IMUNOLOGICA INTERLEUCINA-2/imunol HANSENIASE/imunol TRANSFORMACAO LINFOCITICA LINFOCITOS T/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01401/s

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Id: 13474 Author: Shepard, Charles C; Van Landingham, Rosalind M; Walker, Laura L; Ye, Shang-Zhang Title: Comparison of the immunogenicity of vaccines prepared from viable Mycobacterium bovis BCG, heat-killed Mycobacterium leprae, and a mixture of the two for normal and M. leprae-tolerant mice ..- Source: s.l; s.n; jun. 1983. 8 p. graf. Abstract: Intradermal vaccines consisting of viable Mycobacterium bovis BCG, heat-killed Mycobacterium leprae, or mixtures of the two were titrated in mice in doses of 10(5.2), 10(5.8), 10(6.4), 10(7.0), and 10(7.6) acid-fast bacilli. The immune response was measured by sensitization (48 to 72 h foot pad enlargement on challenge with 10(7.0) heat-killed M. leprae) and by protection against infection with a viable M. leprae challenge. There was increasing response with increasing dose of vaccine, and overall the responses to the three vaccines were similar. At the lowest dose, however, the combination of BCG and M. leprae gave superior protection. The local reaction to the vaccines in the lower dose range was less severe with the M. leprae vaccine. In another experiment, the three vaccines were compared in normal mice and in mice that had been rendered tolerant by intravenous injection of M. leprae. The tolerant mice developed no measurable sensitization on vaccination with M. leprae, but they developed partial but distinct sensitization on vaccination with BCG, alone or in combination with M. leprae. The tolerant mice developed little or no protection with any of the vaccines, however..(AU). Descriptors: MYCOBACTERIUM LEPRAE/imunol HANSENIASE/imunol TOLERÂNCIA IMUNOLOGICA VACINACAO RELACAO DOSE-RESPOSTA IMUNOLOGICA VACINAS BACTERIANAS/imunol VACINA BCG/imunol Limits: ESTUDO COMPARATIVO ANIMAL FEMININO CAMUNDONGOS SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01555/s

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Id: 13329 Author: Salgame, Padmini R; Mahadevan, P. R; Antia, Noshir H Title: Mechanism of immunosuppression in leprosy: presence of suppressor factor(s) from macrophages of lepromatous patients ..- Source: s.l; s.n; jun. 1983. 8 p. tab, graf. Abstract: Human peripheral blood mononuclear cell proliferation induced by Mycobacterium leprae could...(AU). Descriptors: HANSENIASE/imunol LINFOCINAS/anal LINFOCINAS/farmacol FATORES INIBIDORES DA MIGRACAO DE MACROFAGOS/antag FATORES INIBIDORES DA MIGRACAO DE MACROFAGOS/anal FATORES INIBIDORES DA MIGRACAO DE MACROFAGOS/farmacol MYCOBACTERIUM LEPRAE/imunol LINFOCITOS T/imunol LINFOCITOS T SUPRESSORES-EFETORES/imunol - CONCANAVALINA A/farmacol  TOLERÂNCIA IMUNOLOGICA  TRANSFORMACAO LINFOCITICA  MACROFAGOS/imunol  MYCOBACTERIUM/imunol  FATORES SUPRESSORES IMUNOLOGICOS  FATORES DE TEMPO Electronic Medium: http://www.ilsl.br Location: BR191.1; 01218/s

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Id: 13315 Author: Haregewoin, Abebe; Godal, Tore; Mustafa, Abu Salim; Belehu, Ayele; Yemaneberhan, Tabebe Title: T-cell conditioned media reverse T-cell unresponsiveness in lepromatous leprosy ..- Source: s.l; s.n; may 1983. 3 p. ilus, tab. Abstract: In some subjects the infective agent of leprosy, Mycobacterium leprae, causes disseminated (lepromatous) disease. Such subjects have a major role in the transmission of the disease and show deficient T-cell responses both in vivo and in vitro to M. leprae, but not to other antigens. Numerous studies have recently shown that T cells with functional capabilities after initial triggering with antigen can be maintained in a state of continuous proliferation in vitro when cultured in medium containing interleukin 2 (IL-2). Here we have studied the effect of IL-2 rich T-cell conditioned medium on lepromatous peripheral blood mononuclear cells. Our results show that although lepromatous T cells fail to produce IL-2 after exposure to M. leprae they can respond by proliferation to M. leprae in the presence of T-cell conditioned medium, suggesting that the unresponsiveness in lepromatous leprosy results from a deficiency in the production of IL-2 or related factors and not a lack of M. leprae-reactive T cells.(AU). Descriptors: MEIOS DE CULTURA TOLERÂNCIA IMUNOLOGICA INTERLEUCINA-2/imunol HANSENIASE/imunol LINFOCITOS T/imunol - TRANSFORMACAO LINFOCITICA Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01176/s

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Id: 13197 Author: Stanford, J. L Title: Skin testing with mycobacterial reagents in leprosy ..- Source: s.l; s.n; mar. 1984. 12 p. tab, graf. Abstract: Skinh test reagents that have been used to investigate the disease process, immunology and epidemiology of leporsy include preparations of leprosy bacilli themselves, of Mycobacterium tuberculosis and of a range of other mycobacterial species.(AU). Descriptors: HANSENIASE/diag HANSENIASE/imunol ANTIGENO DE MITSUDA/imunol MYCOBACTERIUM/imunol MYCOBACTERIUM LEPRAE/imunol TESTES CUTÂNEOS/métodos TOLERÂNCIA IMUNOLOGICA IMUNOSSUPRESSAO ANTIGENOS DE BACTERIAS/imunol TUBERCULINA/imunol EPITOPOS/anal Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 02109/s

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Id: 12279 Author: Kim, Jenny; Uyemura, Koichi; Van Dyke, Melissa K; Legaspi, Annaliza J; Rea, Thomas H; Shuai, Ke; Modlin, Robert L Title: A role for IL-12 receptor expression and signal transduction in host defense in leprosy ..- Source: s.l; s.n; 2001. 8 p. graf. Descriptors: ANTIGENOS DE BACTÉRIAS PROTEINAS DE LIGAÇAO DE DNA TOLERANCIA IMUNOLOGICA IMUNIDADE CELULAR INTERFERON TIPO II INTERLEUCINA-12 INTERLEUCINA-12 HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE TRANSFORMAÇAO LINFOCITICA MYCOBACTERIUM LEPRAE FOSFORILAÇAO RECEPTORES DA INTERLEUCINA RECEPTORES DA INTERLEUCINA TRANSDUÇAO DE SINAL LINFOCITOS T TRANSATIVADORES CELULAS CULTIVADAS Limits: ESTUDO COMPARATIVO Location: BR191.1; 08631/s

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Id: 10345 Author: Misra, Namita; Selvakumar, M; Singh, S; Bharadwaj, M; Ramesh, V; Misra, R. S; Nath, Indira Title: Monocyte derived IL 10 and PGE2 are associated with the absence of Th 1 cells and in vitro T cell suppression in lepromatous leprosy ..- Source: s.l; s.n; 1995. 6 p. tab, graf. Descriptors: ANTICORPOS DINOPROSTONA DINOPROSTONA TOLERANCIA IMUNOLOGICA INDOMETACINA INTERLEUCINA-10 INTERLEUCINA-10 INTERLEUCINA-10 HANSENIASE LEPROMATOSA TRANSFORMAÇAO LINFOCITICA LINFOPENIA MONOCITOS MONOCITOS CÉLULAS TH1 CÉLULAS TH1 CELULAS CULTIVADAS Location: BR191.1; 07196/s

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Id: 10152 Author: Youhui, Zhang Title: Suppression of cell-mediated immunity due to immune deviation ..- Source: s.l; s.n; 1996. 4 p. . Descriptors: SINDROME DE IMUNODEFICIENCIA ADQUIRIDA TOLERANCIA IMUNOLOGICA IMUNIDADE CELULAR LEISHMANIOSE HANSENIASE NEOPLASIAS LINFOCITOS T Limits: ANIMAL Location: BR191.1; 07117/s

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Id: 9838 Author: Marsh, Bryan J Title: Infectious complications of human T cell leukemia/lymphoma virus type I infection ..- Source: s.l; s.n; 1996. 8 p. tab. Descriptors: HANSENIASE HANSENIASE INFECÇOES OPORTUNISTAS RELACIONADAS COM A AIDS INFECÇOES POR HTLV-I INFECÇOES POR HTLV-I TOLERANCIA IMUNOLOGICA LEUCEMIA-LINFOMA AGUDA DE CÉLULAS T ASSOCIADA A HTLV-I INFECÇOES OPORTUNISTAS PARAPARESIA TROPICAL ESPASTICA INFECÇOES POR STRONGYLIDA INFECÇOES POR STRONGYLIDA TUBERCULOSE PULMONAR TUBERCULOSE PULMONAR Location: BR191.1; 06831/s

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Id: 9703 Author: Dohms, John E Title: Mechanisms of immunosuppression ..- Source: s.l; s.n; 1991. 12 p. tab. Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE AVES ANTIGENOS HIV INFECÇOES POR HIV HIV-1 HIV-1 TOLERANCIA IMUNOLOGICA Location: BR191.1; 06647/s

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Id: 9671 Author: Sieling, Peter A; Abrams, John S; Yamamura, Masahiro; Salgame, Padmini; Bloom, Barry R; Rea, Thomas H; Modlin, Robert L Title: Immunosuppressive roles for Il-10 and IL-4 in human infection: in vitro modulation of T cell response in leprosy ..- Source: s.l; s.n; 1993. 10 p. ilus, tab, graf. Descriptors: LINHAGEM CELULAR FATOR ESTIMULADOR DE COLONIAS DE GRANULOCITOS-MACROFAGOS TOLERANCIA IMUNOLOGICA INTERFERON TIPO II INTERLEUCINA-10 INTERLEUCINA-4 HANSENIASE HANSENIASE HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE TRANSFORMAÇAO LINFOCITICA MYCOBACTERIUM LEPRAE LINFOCITOS T FATOR DE NECROSE TUMORAL/BI Location: BR191.1; 06679/s

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Id: 9659 Author: Vaishnavi, Chetana; Ganguly, Nirmal Kumar; Kaur, Surrinder; Kumar, Bhushan Title: Suppression of ADCC by immune complex formed in vitro in Mycobacterium leprae-infected mice ..- Source: s.l; s.n; 1993. 5 p. tab. Descriptors: HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE CITOTOXICIDADE CELULAR ANTICORPO-DEPENDENTE COMPLEXO ANTIGENO-ANTICORPO CONTAGEM DE COLONIA MICROBIANA TOLERANCIA IMUNOLOGICA IMUNIDADE CELULAR FATORES DE TEMPO Limits: ANIMAL CAMUNDONGOS Location: BR191.1; 06544/s

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Id: 9488 Author: Schauf, Victoria; Holobaugh, Pat; Miller, Pamela; Mittal, Kamal Title: Sensitization in vitro of human peripheral blood mononuclear cells to phenolic glycolipid 1 of Mycobacterium leprae in liposomes ..- Source: s.l; s.n; 1991. 7 p. tab, graf. Descriptors: ANTIGENOS DE BACTÉRIAS POLIIDROXIETIL METACRILATO GLICOLIPIDIOS GLICOLIPIDIOS HEMOCIANINA TOLERANCIA IMUNOLOGICA LEUCOCITOS MONONUCLEARES LIPOSSOMOS TRANSFORMAÇAO LINFOCITICA MYCOBACTERIUM LEPRAE CELULAS CULTIVADAS Limits: IN VITRO Location: BR191.1; 06344/s

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Id: 9339 Author: Rani, Rajni; Zaheer, S. A; Mukherjee, Rama Title: Do human leukocyte antigens have a role to play in differential manifestation of multibacillary leprosy: a study on multibacillary leprosy patients from North India ..- Source: s.l; s.n; 1992. 4 p. tab. Descriptors: ANTIGENOS DE BACTÉRIAS SUSCETIBILIDADE A DOENÇA SUSCETIBILIDADE A DOENÇA ANTIGENOS HLA ANTIGENOS HLA ANTIGENO HLA-DR2 TOLERANCIA IMUNOLOGICA IMUNIDADE CELULAR INDIA HANSENIASE HANSENIASE HANSENIASE HANSENIASE DIMORFA HANSENIASE DIMORFA HANSENIASE DIMORFA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE Limits: ESTUDO COMPARATIVO Location: BR191.1; 06463/s

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