Database : HANSEN Search on : TRANSFORMACAO LINFOCITICA/EF DROGAS [Subject descriptor] References found : 9 [refine] Displaying: 1 .. 9   in format [Detailed]

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Id: 13560 Author: Purtilo, David T; Walsh, Gerald P; Storrs, Eleanor E; Banks, Isaac S Title: Impact of cool temperatures on transformation of human and armadilio lymphocytes ( Dasypus novemcinctus, Linn. ) as related to leprosy ..- Source: s.l; s.n; March 29, 1974. 3 p. tab, graf. Abstract: A CENTURY-LONG search for an unaltered animal in which to study leprosy in humans culminated in the finding that the nine-banded armadillo (Dasypus novemcinctus, Linn.) a primitive mammal native to the southern Western Hemisphere, develops disseminated lepromstous leprosy following inocuation with Mycobacterium leprae isolated from human tissue.(AU). Descriptors: TRANSFORMACAO LINFOCITICA/ef drogas MYCOBACTERIUM LEPRAE/imunol XENARTROS/imunol HANSENIASE/imunol LECTINAS MODELOS ANIMAIS DE DOENCAS ANTIGENOS DE BACTERIAS FRIO Limits: HUMANO ANIMAL MASCULINO FEMININO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00494/s

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Id: 13486 Author: Roselle, G. A; Kauffman, C. A Title: Amphotericin B and 5-fluorocytosine: effects on cell-mediated immunity ..- Source: s.l; s.n; apr. 1980. 7 p. tab, graf. Abstract: Although single-dose amphotericin B therapy appears to be immunostimulatory in mice, no data are available regarding the effects of chronic anti-fungal drug therapy on the immune system. We studied the effects on the guinea-pig cellular immune system of 4 weeks of treatment with amphotericin B, 5-fluorocytosine, or the combination of both drugs. The in vitro lymphocyte response to phytohaemagglutinin and the specific antigen, picryl human serum albumin (picHSA), were not affected by anti-fungal drug treatment. At 1.5 weeks of therapy with amphotericin B, skin test reactivity to picHSA was significantly reduced but returned toward normal by the end of 3.5 weeks of drug therapy. Macrophage migration inhibitory factor production by guinea-pig peripheral blood lymphocytes was significantly reduced after 4 weeks of amphotericin B therapy. No immunostimulatory properties could be ascribed to amphotericin B. 5-fluorocytosine had no effect on cellular immunity.(AU). Descriptors: TESTES CUTÂNEOS FATORES INIBIDORES DA MIGRACAO DE MACROFAGOS/anal CONTAGEM DE LEUCOCITOS LINFOCITOS T/imunol IMUNIDADE CELULAR/ef drogas TRANSFORMACAO LINFOCITICA/ef drogas FLUCITOSINA/farmacol CITOSINA/analog ANFOTERICINA B/farmacol Limits: ANIMAL FEMININO COBAIAS SUPPORT, U.S. GOV'T, NON-P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 01306/s

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Id: 13283 Author: Bahr, G. M; Rook, G. A. W; Stanford, J. L Title: Prostaglandin-dependent regulation of the in vitro paroliferative response to mycobacterial antigens of peripheral blood lymphocytes from normal donors and from patients with tuberculosis or leprosy ..- Source: s.l; s.n; sep. 1981. 8 p. tab, graf. Abstract: The response to soluble mycobacterial antigens of peripheral blood mononuclear cells, from most normal donors, tuberculosis patients or cases of tuberculoid leprosy (TT/BT) was enhanced by the addition of indomethacin. In contrast, indomethacin caused no enhancement of the response of cells from lepromatous leprosy (BL/LL) cases. Moreover the addition of 10-5M prostaglandin E2 (PGE2) failed to inhibit the proliferative responses of cells from the BL/LL patients, although it markedly inhibited the responses of peripheral blood mononuclear cells from the other groups. The addition of PGE2 or indomethacin to cells which had been precultured for 48 hours had no significant effect on the proliferative responses of cells from any of the groups of donors. These results suggest that a normal, prostaglandin-dependent, indomethacin-sensitive regulatory mechanism is absent from the peripheral blood mononuclear cells of BL/LL patients.(AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol ANTIGENOS DE FUNGOS/imunol CANDIDA ALBICANS/imunol DIVISAO CELULAR/ef drogas DINOPROSTONA RELACAO DOSE-RESPOSTA A DROGA INDOMETACINA/farmacol HANSENIASE/imunol TRANSFORMACAO LINFOCITICA/ef drogas MYCOBACTERIUM/imunol - LINFOCITOS/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 00540/s

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Id: 13260 Author: Anderson, R; Gatner, E. M. S; van Rensburg, C. E; Grabow, G; Imkamp, F. M. G. H; Kok, S. K; van Rensburg, A. J Title: In vitro and in vivo effects of dapsone on neutrophil and lymphocyte functions in normal individuals and patients with lepromatous leprosy ..- Source: s.l; s.n; apr. 1981. 9 p. tab, graf. Abstract: The effects of dapsone on polymorphonuclear leukocyte functions and lymphocyte mitogen-induced transformation were assessed in vitro and in vivo in normal individuals and in newly diagnosed untreated patients with lepromatous leprosy. The effects of dapsone on the cell-free generation of superoxide by the xanthine: xanthine oxidase system and iodination of bovine serum albumin by horseradish peroxidase were also investigated. In normal individuals dapsone mediated stimulation of polymorphonuclear leukocyte migration in vitro and vivo. Dapsone had no effect on postphagocytic hexose monophosphate shunt activity in vivo. Similar effects were found in patients with lepromatous leprosy. Dapsone also decreased the inhibitory activity of serum from patients with lepromatous leprosy on normal polymorphonuclear leukocyte migration in vitro. Progressive loss of serum-mediated inhibition of migration was observed after ingestion of dapsone by the patients. Further experiments showed that stimulation of polymorphonuclear leukocyte motility was related to inhibition of lymphocyte transformation at high concentrations in vitro, but had slight stimulatory activity on phytohemagglutinin-induced transformation in controls and patients in vivo.(AU). Descriptors: PEROXIDASE/metab SUPEROXIDOS/metab HANSENIASE/sangue PEROXIDO DE HIDROGÊNIO/metab TRANSFORMACAO LINFOCITICA/ef drogas LINFOCITOS/ef drogas NEUTROFILOS/ef drogas FAGOCITOSE/ef drogas MOVIMENTO CELULAR/ef drogas DAPSONA/farmacol Limits: HUMANO IN VITRO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00756/s

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Id: 11014 Author: Sharma, Nidhi; Sharma, V. K.; Gupta, Anu; Kaur, Inderjeet; Kaur, Sukhbir; Ganguly, N. K Title: Alterations in early biochemical events following T cell activation in leprosy patients ..- Source: s.l; s.n; 1998. 8 p. tab, graf. Descriptors: HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE ANTIGENOS CD CALCIO MEMBRANA CELULAR GLICOLIPIDIOS FOSFATOS DE POLIISOPRENIL RECEPTORES DA INTERLEUCINA 2 INTERLEUCINA-4 INTERLEUCINA-6 LIQUIDO INTRACELULAR TRANSFORMAÇAO LINFOCITICA TRANSFORMAÇAO LINFOCITICA SUB-POPULAÇOES DE LINFOCITOS T LINFOCITOS T ACETATO DE TETRADECANOILFORBOL Location: BR191.1; 07288/s

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Id: 10345 Author: Misra, Namita; Selvakumar, M; Singh, S; Bharadwaj, M; Ramesh, V; Misra, R. S; Nath, Indira Title: Monocyte derived IL 10 and PGE2 are associated with the absence of Th 1 cells and in vitro T cell suppression in lepromatous leprosy ..- Source: s.l; s.n; 1995. 6 p. tab, graf. Descriptors: ANTICORPOS DINOPROSTONA DINOPROSTONA TOLERANCIA IMUNOLOGICA INDOMETACINA INTERLEUCINA-10 INTERLEUCINA-10 INTERLEUCINA-10 HANSENIASE LEPROMATOSA TRANSFORMAÇAO LINFOCITICA LINFOPENIA MONOCITOS MONOCITOS CÉLULAS TH1 CÉLULAS TH1 CELULAS CULTIVADAS Location: BR191.1; 07196/s

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Id: 10338 Author: Mesret, Yohannes; Reed, Allen H; Howe, Rawleigh Title: Proliferative responses of T cells from the skin and nerve lesions of leprosy patients ..- Source: s.l; s.n; 1995. 10 p. tab, graf. Descriptors: ANTIGENOS CD28 ANTIGENOS CD3 ANTIGENOS CD45 INTERFERON TIPO II RECEPTORES DA INTERLEUCINA 2 INTERLEUCINA-2 INTERLEUCINA-4 HANSENIASE HANSENIASE TRANSFORMAÇAO LINFOCITICA TRANSFORMAÇAO LINFOCITICA MITOGENOS NERVOS PERIFÉRICOS FITOHEMAGLUTININAS PELE LINFOCITOS T LINFOCITOS T CELULAS CULTIVADAS Location: BR191.1; 07189/s

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Id: 10264 Author: Mazumder, Shibnath; Nath, Indira; Dhar, M. M Title: Immunomodulation of human T cell responses with receptor selective enkephalins ..- Source: s.l; s.n; 1993. 6 p. graf. Descriptors: ADJUVANTES IMUNOLOGICOS SEQUENCIA DE AMINOACIDOS ENCEFALINA METIONINA ENCEFALINAS ENCEFALINAS IMUNOSSUPRESSORES HANSENIASE TRANSFORMAÇAO LINFOCITICA DADOS DE SEQUENCIA MOLECULAR PEPTIDIOS CICLICOS RECEPTORES OPIOIDES DELTA RECEPTORES OPIOIDES DELTA RECEPTORES OPIOIDES KAPPA RECEPTORES OPIOIDES MU RECEPTORES OPIOIDES MU FORMAÇAO DE ROSETA LINFOCITOS T LINFOCITOS T LINFOCITOS T TUBERCULOSE PULMONAR D-Penicilina (2,5)-Encefalina Limits: IN VITRO Location: BR191.1; 06943/s

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Id: 10189 Author: De Jong, Rolien; Janson, Anneke A. M; Faber, William R; Naafs, Ben; Ottenhoff, Tom H. M Title: IL-2 and IL-12 act in synergy to overcome antigen-specific T cell unresponsiveness in mycobacterial disease ..- Source: s.l; s.n; 1997. 8 p. tab, graf. Descriptors: SINERGISMO DE DROGAS IMUNIDADE CELULAR INTERLEUCINA-12 INTERLEUCINA-12 INTERLEUCINA-2 INTERLEUCINA-2 TRANSFORMAÇAO LINFOCITICA PROTEINAS RECOMBINANTES LINFOCITOS T Location: BR191.1; 07102/s

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