Database : HANSEN Search on : VACINAS [Subject descriptor] References found : 66 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 19631 Author: Storrs, Eleanor E. Title: A lost Talisman: catastrophic decline in yields of leprosy bacilli from armadillos used for vaccine production. Source: Int. J. Lepr;67(1):67-70, Mar., 1999. tab. Descriptors: Mycobacterium leprae/imunol Mycobacterium leprae/fisiol Vacinas/imunol Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1999/pdf/v67n1/v67n1cor03.pdf / en Location: BR191.1

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Id: 17691 Author: Scollard, D. M; Adams, L. B; Gillis, T. P; Krahenbuhl, J. L; Truman, R. W; Williams, D. L Title: The continuing challenges of leprosy ..- Source: s.l; s.n; 2006. 44 p. ilus, tab. Abstract: Leprosy is best understood as two conjoined diseases. The first is a chronic mycobacterial infection that elicits an extraordinary range of cellular immune responses in humans. The second is a peripheral neuropathy that is initiated by the infection and the accompanying immunological events. The infection is curable but not preventable, and leprosy remains a major global health problem, especially in the developing world, publicity to the contrary notwithstanding. Mycobacterium leprae remains noncultivable, and for over a century leprosy has presented major challenges in the fields of microbiology, pathology, immunology, and genetics; it continues to do so today. This review focuses on recent advances in our understanding of M. leprae and the host response to it, especially concerning molecular identification of M. leprae, knowledge of its genome, transcriptome, and proteome, its mechanisms of microbial resistance, and recognition of strains by variable-number tandem repeat analysis. Advances in experimental models include studies in gene knockout mice and the development of molecular techniques to explore the armadillo model. In clinical studies, notable progress has been made concerning the immunology and immunopathology of leprosy, the genetics of human resistance, mechanisms of nerve injury, and chemotherapy. In nearly all of these areas, however, leprosy remains poorly understood compared to other major bacterial diseases. (AU). Descriptors: Antiinfecciosos/TU Proteínas de Bactérias/ME Vacinas Bacterianas Modelos Animais de Doenças Suscetibilidade à Doença/IM Resistência Bacteriana a Drogas Genes Bacterianos/GE Predisposição Genética para Doença Genoma Bacteriano Imunidade Celular Imunidade Natural/GE Hansenostáticos/PD/TU Hanseníase/*/DI/MI/TH Mycobacterium leprae/*/CH/DE/IP/PH Nervos Periféricos/MI Doenças do Sistema Nervoso Periférico/MI/PA Reação em Cadeia da Polimerase Research Support, N.I.H., Extramural Células de Schwann/IM/MI Limits: HUMANO ANIMAL CAMUNDONGOS SUPPORT, NON-U.S. GOV'T Location: BR191.1; 09365/S

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Id: 17429 Author: Zuñiga, M; Convit, J Title: Inmunoterapia de la lepra ?- Source: s.l; s.n; s.d. 13p p. . Descriptors: HANSENIASE/imunol HANSENIASE/patol VACINAS/bios Limits: RELATO DE CASO Location: BR191.1; 00653/s

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Id: 17337 Author: Convit, Jacinto; Borges, Rafael; Ulrich, Marian; Aranzazu, Nacarid; Pinardi, Maria E; Parra, Juan Jose. Title: Leprosy vaccines. Source: Hansen. Int;28(1):13-18, jan.-jun. 2003. . Descriptors: HANSENIASE/quimioter HANSENIASE/imunol HANSENIASE/terap VACINAS/imunol VACINAS/uso terap Electronic Medium: http://hansen.bvs.ilsl.br/textoc/hansenint/v21aov29/2003/PDF/v28n1/v28n1a1eng.pdf / en Location: BR191.1

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Id: 17336 Author: Convit, Jacinto; Borges, Rafael; Ulrich, Marian; Aranzazu, Nacarid; Pinardi, Maria E; Parra, Juan Jose. Title: Vacinas para a hanseniase / Leprosy vaccines Source: Hansen. Int;28(1):7-12, jan.-jun. 2003. . Descriptors: HANSENIASE/quimioter HANSENIASE/imunol HANSENIASE/terap VACINAS/imunol VACINAS/uso terap Electronic Medium: http://hansen.bvs.ilsl.br/textoc/hansenint/v21aov29/2003/PDF/v28n1/v28n1a01.pdf / pt Location: BR191.1

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Id: 17233 Author: Castilho, Mirian Lane de O. Rodrigues Title: Correlação entre BCG intradérmico e linfoproliferação, produção e expressão de RNAm das citocinas IFN-y, IL-12, IL-10 e IL-4, níveis de anti-PGL-1 em pacientes com hanseníase e em seus comunicantes ?- Source: Ribeirao Preto; s.n; 2001. 184 p. tab, graf, ilus. Thesis: Present for Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto presented for the degree Doutor. Abstract: O BCGid é preconizado para a imunoprofilaxia da hanseníase. Apesar de frequentemente utilizado, especialmente em comunicantes de doentes de áreas endêmicas, os seus mecanismos imunológicos de estimulação protetora são ainda pouco conhecidos para a doença. Como desenvolvimento da hanseníase correlaciona-se diretamente com a resposta imunecelular, avaliou-se a relação entre a aplicação de uma dose de BCGid em doentes e comunicantes, associando com alterações imunecelulares. A avaliação foi através da produção de anticorpos específicos do M.leprae (Anti-PGL-1), da linfoproliferação, da quantificação das citocinas IL-4, IL-10, IL-12 e IFN-y e da expressão gênica das referidas citocinas em sangue periférico. Verificou-se ainda se houve diferença entre a resposta imunecelular induzida pelo BCGid em doentes e comunicantes. Foram avaliados 34 indivíduos, antes e após o BCGid, sendo 15 doentes e 19 comunicantes sadios(AU). Descriptors: HANSENIASE IMUNIZACAO VACINAS/imunol Limits: RELATO DE CASO Location: BR191.1; WC335.501, C278c

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Id: 15511 Author: Johansen, F. A; Munday, C. P. Title: Immediate effects of prophylactic antityphoid vaccination of lepers. Source: Int. J. Lepr;5(1):71-73, Jan.-Mar. 1937. tab. Descriptors: HANSENIASE HANSENIASE/clas HANSENIASE/quimioter HANSENIASE/prev HANSENIASE/imunol VACINAS TIFICAS-PARATÍFICAS/ef adv VACINAS TIFICAS-PARATÍFICAS/uso terap Electronic Medium: http://www.ilsl.br Location: BR191.1

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Id: 13872 Author: Convit, Jacinto; Monzón, H; Pinardi, M. E; Aránzazu, N; Ulrich, M Title: The development of an active vaccine against leprosy ..- Source: s.l; s.n; 1979. 3 p. . Abstract: The development of an effective vaccine against leprosy will be directed to obtain a product which can modify the immunological response of the population susceptible to develop the disease and to avoid the occurence of lepromatous, infecting forms. This action would interrupt the transmission chain, producing a important decrease in tge incidence of the disease. The measures used at present fotr anti-leprosy campaigns such as early diagnosis, control of contacts, out-patient treatment and prevention of disabilities, can be effective if applied with a high degree of efficiency and during extended periods of time. If to these measures we could add a vaccine, we would be able to reduce considerably the expense and time needes for keeping the disease under control. The development of a vaccine against leprosy is based on the assumption the disease is due to an immunological defect of the host which is specific against this particular bacterium. Previous work done by us, where we have obtained highly favorable immunological modifications in pre-lepromatous, indeterminate patients and in Mitsuda negative contacts and, partially, in lepromatous patients, using an injection of a mixture of armadillo M. leprae and BCG, serves as basis for our proposal of using this same type of preparation as an anti-leprosy vaccine in susceptible persons, where ity would evoke a positive immunological change which would prevent the onset of infecting forms of the disease.(AU). Descriptors: VACINAS BACTERIANAS/admin HANSENIASE/imunol HANSENIASE/prev MYCOBACTERIUM LEPRAE/imunol VENEZUELA Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00575/s

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Id: 13735 Author: Ngamying, Maeya; Sawanpanyalert, Pathom; Butraporn, Raywadee; Nikasri, Junjira; Cho, Sang-Nae; Levy, Louis; Brennan, Patrick J Title: Effect of vaccination with refined components of the organism on infection of mice with Mycobacterium leprae ..- Source: s.l; s.n; 2003. 3 p. tab. Abstract: Only native products of Mycobacterium leprae, whether cell wall, cytosol, or membrane derived, can confer protective immunity against challenge in the mouse footpad. Previously, recombinant proteins were shown to be ineffective. The cell wall skeleton-the mycolyl-arabinogalactan-peptidoglycan complex-devoid of proteins is not protective. (AU). Descriptors: HANSENIASE/prev VACINAS BACTERIANAS/imunol ESQUELETO DA PAREDE CELULAR/imunol CAMUNDONGOS ENDOGÂMICOS BALB C MYCOBACTERIUM BOVIS/imunol MYCOBACTERIUM LEPRAE/imunol VACINACAO Limits: ANIMAL FEMININO CAMUNDONGOS SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1

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Id: 13712 Author: Convit, Jacinto Title: Fighting leprosy and other endemic diseases ..- Source: s.l; s.n; 2002. 4 p. . Abstract: As part of its 100th-anniversary celebration, the Pan American Health Organization has named 12 persons as "Public Health Heroes of the Americas" in recognition of their noteworthy contributions to public health in the Region of the Americas. Over the course of this year, the Revista Panamericana de Salud Pública/Pan American Journal of Public Health will be carrying pieces written by or about these heroes. (AU) Como parte de la celebración de su Centenario, la Organización Panamericana de la Salud (OPS) ha distinguido con el título de Héroes de la Salud Pública a 12 personalidades que se han destacado por su valiosa contribución a la salud en el continente americano. A lo largo de este año, la Revista Panamericana de Salud Pública/Pan American Journal of Public Health publicará una serie de escritos de los mismos galardonados o acerca de ellos. (AU). Descriptors: SURTOS DE DOENCAS/PC LEISHMANIA/IM HANSENIASE/*EP/*PC VACINAS SINTETICAS/IM/TU Limits: ANIMAL HUMANO Location: BR191.1; 09073/s

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Id: 13474 Author: Shepard, Charles C; Van Landingham, Rosalind M; Walker, Laura L; Ye, Shang-Zhang Title: Comparison of the immunogenicity of vaccines prepared from viable Mycobacterium bovis BCG, heat-killed Mycobacterium leprae, and a mixture of the two for normal and M. leprae-tolerant mice ..- Source: s.l; s.n; jun. 1983. 8 p. graf. Abstract: Intradermal vaccines consisting of viable Mycobacterium bovis BCG, heat-killed Mycobacterium leprae, or mixtures of the two were titrated in mice in doses of 10(5.2), 10(5.8), 10(6.4), 10(7.0), and 10(7.6) acid-fast bacilli. The immune response was measured by sensitization (48 to 72 h foot pad enlargement on challenge with 10(7.0) heat-killed M. leprae) and by protection against infection with a viable M. leprae challenge. There was increasing response with increasing dose of vaccine, and overall the responses to the three vaccines were similar. At the lowest dose, however, the combination of BCG and M. leprae gave superior protection. The local reaction to the vaccines in the lower dose range was less severe with the M. leprae vaccine. In another experiment, the three vaccines were compared in normal mice and in mice that had been rendered tolerant by intravenous injection of M. leprae. The tolerant mice developed no measurable sensitization on vaccination with M. leprae, but they developed partial but distinct sensitization on vaccination with BCG, alone or in combination with M. leprae. The tolerant mice developed little or no protection with any of the vaccines, however..(AU). Descriptors: MYCOBACTERIUM LEPRAE/imunol HANSENIASE/imunol TOLERÂNCIA IMUNOLOGICA VACINACAO RELACAO DOSE-RESPOSTA IMUNOLOGICA VACINAS BACTERIANAS/imunol VACINA BCG/imunol Limits: ESTUDO COMPARATIVO ANIMAL FEMININO CAMUNDONGOS SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01555/s

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Id: 13456 Author: Shepard, Charles C; Walker, Laura L; Van Landingham, Rosalind Title: Heat stability of Mycobacterium leprae immunogenicity ..- Source: s.l; s.n; oct. 1978. 7 p. tab, graf. Abstract: The protection provided to mice by vaccines administered intradermally was measured after footpad challenge with Mycobacterium leprae. The protection offered by M. leprae suspensions was not decreased when the vaccines were killed by 60 degrees C heat or at the higher temperatures tested, which included 215 degrees C (autoclave). Even highly purified suspensions retained their immunogenicity. In contrast, the vaccine protection provided by intradermal M. bovis (strain BCG) was markedly reduced when heated to 60 degrees C. The enlargement of the lymph nodes regional to the intradermal vaccines was measured and found generally to parallel the vaccine protection provided by M. leprae and by BCG.(AU). Descriptors: MYCOBACTERIUM BOVIS HANSENIASE/imunol MYCOBACTERIUM LEPRAE/imunol INJECOES SUBCUTÂNEAS INJECOES INTRADERMICAS VACINA BCG IMUNIDADE CELULAR VACINAS BACTERIANAS/admin VACINAS BACTERIANAS/imunol VACINAS BACTERIANAS/normas - CONGELAMENTO  CALOR Limits: ANIMAL CAMUNDONGOS SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 00293/s

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Id: 13380 Author: Shepard, Charles C; van Landingham, Rosalind; Walker, Laura L Title: Searches among mycobacterial cultures for antileprosy vaccines ..- Source: s.l; s.n; sep. 1980. 6 p. tab, graf. Abstract: All mycobacteria species share some antigens, so there may be cultivable mycobacterial cultures that can provide vaccine protection against leprosy. Vaccine protection against Mycobacterium leprae infections in mice has been demonstrated for M. leprae itself, as living or heat-killed suspensions, and for Mycobacterium bovis (BCG), as living suspensions. Results are reported here with 17 other cultures. The mycobacterial suspensions were injected intradermally, and the mice were challenged in the footpad with infectious suspensions of M. leprae. In two experiments the mice were also challenged by footpad injections of 10(7) heat-killed M. leprae so the footpad enlargment could be measured. That some mycobacterial suspensions were immunogenic for some of their own antigens was suggested by reactions at the vaccine site and enlargement of the regional lymph nodes. Some mycobacterial suspensions also stimulated footpad enlargement on challenge by homologous suspensions or by challenge with M. leprae suspensions. Consistent protection against infectious challenge with M. leprae was observed only with BCG and M. leprae, however...(AU). Descriptors: MYCOBACTERIUM/imunol MYCOBACTERIUM BOVIS/imunol LINFONODOS/imunol HANSENIASE/prev MYCOBACTERIUM LEPRAE/imunol VACINAS BACTERIANAS/uso terap VACINA BCG/uso terap Limits: ANIMAL FEMININO CAMUNDONGOS SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01536/s

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Id: 13309 Author: Bhide, M. B; Dholam, S. B; Chatterjee, B. R Title: Inhibition of foot pad multiplication of M. leprae in mice vaccinated with leproma derived M. leprae precursor coccoid organism and passive transfer of DTH response to normal mice through infusion of splenic cells of such vaccinated mice ..- Source: s.l; s.n; oct. 1981. 8 p. graf. Abstract: Inhibition of foot pad multiplication of M. leprae in mice vaccinated with leproma derived M. leprae precursor coccoid organism and passive transfer of DTH response to normal mice through infusion of splenic cells of such vaccinated mice.(AU). Descriptors: VACINAS BACTERIANAS/imunol HIPERSENSIBILIDADE TARDIA/imunol IMUNIZACAO PASSIVA MYCOBACTERIUM LEPRAE/imunol BACO/transpl VACINACAO Limits: ANIMAL CAMUNDONGOS SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 00813/s

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Id: 12911 Author: Organização Mundial da Saúde*. Title: Vaccination trials against leprosy: a meeting of the epidemiology subgroup of the scientific working group on the immunology of leprosy ..- Source: Geneva; s.n; feb., 1985. 18 p. . (TDR/IMMLEP/EPD/85.3).   (TDR/IMMLEP/EPD/85.3). Descriptors: HANSENIASE HANSENIASE VACINAS Location: BR191.1; 0748/d.a

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Id: 12587 Author: Souza Araujo, Heraclides Cesar de Title: A lepra: varias tentativas de cura ..- Source: São Paulo; s.n; 1941. 48 p. . Descriptors: HANSENIASE CHAULMOOGRA VACINAS Location: BR191.1; 0665/d.a

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Id: 12334 Author: Pereira, Octaviano de Loiola Title: On the effects of anti-variolic vaccination in lepers ..- Source: s.l; s.n; s.d. 4 p. ilus. Descriptors: HANSENIASE VACINAS VARIOLA Location: BR191.1; 0233/f

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Id: 12310 Author: Truoc, Le Van; Ly, Ho Minh; Thuy, Nguyen Kim; Trach, Dang Duc; Stanford, C. A; Stanford, J. L Title: Vaccination against leprosy at Ben San Leprosy Center, Ho Chi Minh City, Vietnam ..- Source: s.l; s.n; 2001. 8 p. tab. Descriptors: ADOLESCENCIA VACINA BCG VACINAS BACTERIANAS PRÉ-ESCOLAR ESQUEMA DE IMUNIZAÇAO HANSENIASE HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM TESTES CUTANEOS FATORES DE TEMPO VACINAS DE PRODUTOS INATIVADOS VIETNA Location: BR191.1; 08663/s

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Id: 12232 Author: Oliveira, Martha M; Charlab, Rosane; Pessolani, Maria Cristina V Title: Mycobacterium bovis BCG but not mycobacterium leprae induces TNF-alpha secretion in human monocytic THP-1 cells ..- Source: Rio de Janeiro; s.n; Oct. 2001. 6 p. tab, graf. Descriptors: VACINA BCG VACINAS BACTERIANAS BOVINOS HANSENIASE MONOCITOS MONOCITOS MYCOBACTERIUM BOVIS MYCOBACTERIUM LEPRAE FATOR DE NECROSE TUMORAL/BI/*SE CELULAS CULTIVADAS Limits: ANIMAL Location: BR191.1; 08634/s

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Id: 12207 Author: Jaja, Giovanni Title: Manifestazione acute post-vaccinali nella lebbra ..- Source: Cressati - Bari; s.n; 1929. 20 p. ilus. Descriptors: HANSENIASE HANSENIASE VACINAS Location: BR191.1; 0372/f

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