Database : HANSEN Search on : COMPLEMENTO [Subject descriptor] References found : 17 [refine] Displaying: 1 .. 17   in format [Detailed]

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Id: 15451 Author: Pereira, Paulo C. R. Title: La réaction de fixation du complément avec l'antigène de Witebsky, Klingenstein et Kuhn dans la lèpre. Source: Int. J. Lepr;4(2):207-214, Apr.-Jun. 1936. tab. Abstract: En considérant les résults obtenus en pratiquant la réaction de Witebsky, Klingenstein et Kuhn avec le sérum sanguin de 107 lépreux, nous voyons que la réaction a été positive sur 100 pour cent de 12 cas de lèpre cutanée et 35 de lèpre mixte, et sur 80 pour cent de 60 cas de lèpre nerveuse. Il se pourrait que ce dernier pourcentage soit supérieur si nous avions examiné sans distinction n'importe quel cas de lèpre nerveuse, et non comme cela a été fait, en recherchant soigneusement les cas des lésions extinctes dont nous disposions. Les réactions des malades de la lèpre nerveuse ont été moins intenses que celles de la lèpre cutanée mixte. Des 84 sérums de personnes ayant un contact continuel avec des lépreux, la plus grande partie représentée par des fils et conjoints de malades, 53 on donné une réaction negative, 4 douteuse, et 27 positive. Des cas négatifs, 9 ont présenté quelques symptômes qui pourraient être liés à la lèpre....(AU). Descriptors: HANSENIASE/sangue HANSENIASE/diag HANSENIASE/imunol - ANTIGENOS/uso diag  ANTIGENOS/imunol  COMPLEMENTO Limits: HUMANO Location: BR191.1

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Id: 13539 Author: Ramanathan, V. D; Thyagi, P; Ramanathan, U; Katoch, K; Ramu, G Title: A sequential study of circulating immune complexes, complement and immunoglobulins in borderline tuberculoid leprosy patients with and without reactions ..- Source: s.l; s.n; 1998. 8 p. tab, graf. Abstract: Sequential estimates of the levels of circulating immune complexes (CIC), complement catabolic fragment C3d, complement-mediated immune complex solubilization (CMS) and immunoglobulins were made in 24 newly diagnosed with borderline tuberculoid leprosy over a 20 month period after initiation of chemotherapy. Fourteen of these patients had not suffered from reversal reactions either at the time of presentation or during the follow-up. The levels of CIC were evaluated in them from the third to the eleventh month after starting chemotherapy and immunoglobulin G (IgG) levels were evaluated up to eight months. The concentrations of C3d and immunoglobulins A (IgA) and M (IgM) were normal in these patients. The other ten patients had reversal reaction at the time of diagnosis which subsided by the third month after starting treatment. They did not have reversal reactions later. The levels of CIC and IgG were elevated and those of CMS were depressed throughout the study period. Serum C3d level was initially elevated but came down to normal by the third month while IgA and IgM levels were within normal limits. The relevance of these findings to the genesis of reversal reaction is discussed in this communication.(AU). Descriptors: COMPLEXO ANTIGENO-ANTICORPO/sangue COMPLEMENTO 3D/anal ANTIGENO DE MITSUDA IMUNOGLOBULINAS/sangue HANSENOSTATICOS/uso terap HANSENIASE TUBERCULOIDE/quimioter HANSENIASE TUBERCULOIDE/imunol FATORES DE TEMPO Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE Location: BR191.1; 09164/s

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Id: 13417 Author: Bjorvatn, B; Barnetson, R. S; Kronvall, G; Zubler, R. H; Lambert, P. H Title: Immune complexes and complement hypercatabolism in patients with leprosy ..- Source: s.l; s.n; dec. 1976. 9 p. tab, graf. Abstract: The occurrence of immune complexes in the serum and the level of the C3 breakdown product C3d in the plasma from patients with leprosy were studied by quantitative methods and the results were compared in various forms of the disease. These studies were performed on sixty-two samples from twenty-six patients. The serum 125I-C1q binding activity was found to be increased by more than 2 s.d., as compared to the normal values, in most of the sera from patients with erythema nodosum leprosum (ENL) (80%) and uncomplicated lepromatous leprosy (82%), but also in the sera from patients with tuberculoid leprosy (58%). In vitro studies suggested that immune complexes involving mycobacterial antigens were present in leprosy sera. An increased C3d level (greater than 2s.d.) was also found in most of the plasma from patients with ENL (70%), but rarely in the plasma from patients with uncomplicated lepromatous leprosy (18%) and never in tuberculoid leprosy patients' plasma. The absence of a significant correlation between the 125I-C1q binding activity and the C3d level in leprosy patients may suggest that extravascular immune complexes are involved in the complement activation occurring in ENL. The quantitation of C3d in plasma may be of some practical interest in the early diagnosis of ENL complications of leprosy.(AU). Descriptors: COMPLEXO ANTIGENO-ANTICORPO COMPLEMENTO 1/metab COMPLEMENTO 3/metab TESTES DE FIXACAO DE COMPLEMENTO ERITEMA NODOSO/imunol HANSENIASE/imunol Limits: HUMANO ADULTO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00016/s

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Id: 13404 Author: Faber, W. R; Leiker, D. L Title: Immunofluorescence studies across the leprosy spectrum ..- Source: s.l; s.n; June 29, 1978. 8 p. ilus, tab. Abstract: Forty biopsies from skin lesions of untreated (24) and treated (16) leprosy patients, representing the whole leprosy spectrum, were examined by means of immunofluorescence (IF) methods. Only few or no cells staining with FTC-labelled antihuman immunoglobulin antisera were found in the lesional skin of all patients examined. Sparse IgM-deposits along the basement membrane of the epidermis were observed in a few borderline lepromatous and lepromatous patients. Complement deposits along the basement membrane of the epidermis and in the vessel walls were found in tuberculoïd as well as in lepromatous patients. Complement and in a lesser number IgG-deposits were observed around sweat glands and sometimes around sweat gland ducts and other skin appendages. Autofluorescing macrophages were noted in patients at the lepromatous side of the leprosy spectrum; approximately half of these patients showed complement deposits in an around these cells.(AU). Descriptors: COMPLEMENTO/anal IMUNOFLUORESCÊNCIA IMUNOGLOBULINA G/anal IMUNOGLOBULINA M/anal HANSENIASE/imunol MACROFAGOS/imunol PELE/imunol Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00970/s

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Id: 13351 Author: Moran, C. J; Ryder, G; Turk, J. L; Waters, M. F Title: Evidence for circulating immune complexes in lepromatous leprosy ..- Source: s.l; s.n; September 16, 1972. 2 p. tab. Abstract: Sera from patients with lepromatous leprosy react with the Clq component of complement in vitro. The incidence of sera that react in this way is higher in patients with active erythema nodosum leprosum (E.N.L.). This is further, although circumstantial, evidence for the immune complex aetiology of E.N.L. and opens a way for the more precise identification of the antigen involved.(AU). Descriptors: COMPLEMENTO ERITEMA NODOSO/imunol SOROS IMUNES HANSENIASE/imunol TESTES DE PRECIPITINA PROGNOSTICO COELHOS/imunol COMPLEXO ANTIGENO-ANTICORPO Limits: HUMANO ANIMAL Electronic Medium: http://www.ilsl.br Location: BR191.1; 01835/s

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Id: 13350 Author: Bjorvatn, B; Barnetson, R. S; Kronvall, G; Zubler, R. H; Lambert, P. H Title: Immune complexes and complement hypercatabolism in patients with leprosy ..- Source: s.l; s.n; dec. 1976. 9 p. tab, graf. Abstract: The occurrence of immune complexes in the serum and the level of the C3 breakdown product C3d in the plasma from patients with leprosy were studied by quantitative methods and the results were compared in various forms of the disease. These studies were performed on sixty-two samples from twenty-six patients. The serum 125I-C1q binding activity was found to be increased by more than 2 s.d., as compared to the normal values, in most of the sera from patients with erythema nodosum leprosum (ENL) (80%) and uncomplicated lepromatous leprosy (82%), but also in the sera from patients with tuberculoid leprosy (58%). In vitro studies suggested that immune complexes involving mycobacterial antigens were present in leprosy sera. An increased C3d level (greater than 2s.d.) was also found in most of the plasma from patients with ENL (70%), but rarely in the plasma from patients with uncomplicated lepromatous leprosy (18%) and never in tuberculoid leprosy patients' plasma. The absence of a significant correlation between the 125I-C1q binding activity and the C3d level in leprosy patients may suggest that extravascular immune complexes are involved in the complement activation occurring in ENL. The quantitation of C3d in plasma may be of some practical interest in the early diagnosis of ENL complications of leprosy.(AU). Descriptors: COMPLEMENTO 3/metab TESTES DE FIXACAO DE COMPLEMENTO ERITEMA NODOSO/imunol HANSENIASE/imunol COMPLEMENTO 1/metab COMPLEXO ANTIGENO-ANTICORPO Limits: HUMANO ADULTO Electronic Medium: http://www.ilsl.br Location: BR191.1; 01833/s

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Id: 13336 Author: Valentijn, R. M; Faber, W. R; Lai A Fat, R. F; Chan Pin Jie, J. C; Daha, M. R; van Es, L. A Title: Immune complexes in leprosy patients from an endemic and a nonendemic area and a longitudinal study of the relationship between complement breakdown products and the clinical activity of erythema nodosum leprosum ..- Source: s.l; s.n; feb. 1982. 8 p. tab, graf. Abstract: The sera from leprosy patients living in Surinam (endemic) and 41 leprosy patients living in The Netherlands (nonendemic) were tested for circulating immune complexes (CIC) with the Clq-binding assay and the conglutinin-binding assay and for complement.(AU). Descriptors: COMPLEXO ANTIGENO-ANTICORPO/anal COMPLEMENTO 1Q COMPLEMENTO 3/anal ENZIMAS ATIVADORAS DO COMPLEMENTO/metab ERITEMA NODOSO/epidemiol ERITEMA NODOSO/imunol HANSENIASE/clas HANSENIASE/epidemiol HANSENIASE/imunol - COMPLEMENTO/anal  ESTUDOS LONGITUDINAIS  SURINAME  PAISES BAIXOS Limits: HUMANO MASCULINO FEMININO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01133/s

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Id: 13334 Author: Geniteau, M; Adam, C; Verroust, P; Pasticier, A; Saimot, G; Coulaud, J. P; Languillon, J Title: Les complexes immuns et le complément dans la lèpre Immune complexes and complement in leprosy- Source: s.l; s.n; Dec. 1981. 4 p. tab, graf. Abstract: The sera of 87 Senegalese patients with various forms of leprosy were investigated. Two of the most reliable methods were used to detect circulating immune complexes : the radiolabelled C1q binding test and the Raji cell binding technique. Several fractions of complement, including C3, C4, factor B and the C3d product of C3 were also assayed. A material having the properties of immune complexes was detected in lepromatous and reactional leprosy. In tuberculous leprosy, only the Raji cell binding technique gave positive results. C3 and C4 were normal or slightly raised, but C3d was increased in all forms of the disease. There was no significant correlation between C3d values and the results of immune complexes detection tests.(AU). Descriptors: COMPLEMENTO 4/anal COMPLEMENTO 3/anal COMPLEXO ANTIGENO-ANTICORPO/anal HANSENIASE/imunol - SENEGAL Limits: HUMANO RESUMO EM INGLES Electronic Medium: http://www.ilsl.br Location: BR191.1; 01123/s

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Id: 13325 Author: Moran, C. J; Ryder, G; Turk, J. L; Waters, M. F. R Title: Evidence for circulating immune complexes in lepromatous leprosy ..- Source: s.l; s.n; sep. 1972. 2 p. tab. Abstract: Sera from patients with lepromatous leprosy react with the Clq component of complement in vitro. The incidence of sera that react in this way is higher in patients with active erythema nodosum leprosum. (AU). Descriptors: COMPLEXO ANTIGENO-ANTICORPO COMPLEMENTO ERITEMA NODOSO/imunol SOROS IMUNES HANSENIASE/imunol TESTES DE PRECIPITINA PROGNOSTICO COELHOS/imunol Limits: HUMANO ANIMAL Electronic Medium: http://www.ilsl.br Location: BR191.1; 01272/s

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Id: 13321 Author: Saha, Kunal; Mittal, Mmdan M; Ray, S. N Title: Consequences of smallpox vaccination in leprosy patients ..- Source: s.l; s.n; sep. 1973. 8 p. tab. Abstract: This study illustrates the consequences of smallpox revaccination in 45 lepromatous, 28 tuberculoid, and 47 normal individuals. Results obtained with leprosy were associated with a relative anergy against the vaccinia virus, the anergy being minimal in the tuberculoid leprosy but marked in the cases with lepromatous leprosy.(AU). Descriptors: HIPERSENSIBILIDADE TARDIA/imunol IMUNIDADE CELULAR IMUNOGLOBULINA A/anal IMUNOGLOBULINA G/anal IMUNOGLOBULINA M/anal INJECOES INTRADERMICAS HANSENIASE/imunol VACINA ANTIVARIOLICA/admin VACINACAO/ef adv VIRUS DA VACÍNIA/imunol - FORMACAO DE ANTICORPOS  CALOR  HEMAGLUTINACAO  IMUNIZACAO SECUNDARIA  INIBICAO (PSICOLOGIA)  MERCAPTOETANOL  COMPLEMENTO/anal  IMUNODIFUSAO Limits: HUMANO ADULTO Electronic Medium: http://www.ilsl.br Location: BR191.1; 01256/s

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Id: 13314 Author: Tung, K. S; Kim, B; Bjorvatn, B; Kronvall, G; McLaren, L. C; Williams, R. C Title: Discrepancy between Clq deviation and Raji cell tests in detection of circulating immune complexes in patients with leprosy ..- Source: s.l; s.n; aug. 1977. 6 p. ilus, tab, graf. Abstract: Samples of serum from 45 patients with different clinical forms of leprosy and from 17 patients with systemic lupus erythematosus were studied in parallel for circulating immune complexes with use of two different in vitro tests adjusted to the same degree of sensitivity. The Clq deviation test relied upon the reaction of the complement component Clq with immune complexes. The Raji cell test detected complement-fixed immune complexes that bound to the complement receptors on cultured, bone marrow-derived lymphocyte-like Raji cells. Thirty (67%) of 45 patients with leprosy showed immune complexes according to the Clq deviation test; however, only two (7%) of the 30 samples of sera with positive Clq test results were positive by the Raji cell test. In contrast, 54% of 13 samples of sera from patients with systemic lupus erythematosus positive by the Clq test were positive according to the Raji cell test. Since Clq is known to react with DNA as well as with bacterial antigens, the Clq reaction may in fact be detecting antigenemia in many instances. Considerable caution is warranted in application of sensitive screening tests for assay of circulating immune complexes in various states of infectious diseases.(AU). Descriptors: HANSENIASE/imunol TECNICAS IMUNOLOGICAS DNA/imunol DNA/metab ANTICORPOS COMPLEXO ANTIGENO-ANTICORPO LINHAGEM CELULAR COMPLEMENTO/metab COMPLEMENTO 1/metab LUPUS ERITEMATOSO SISTÊMICO/imunol Limits: ESTUDO COMPARATIVO HUMANO SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 01271/s

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Id: 10235 Author: Messias, I. J. T. de; Santamaria, J; Brenden, M; Reis, A; Mauff, G Title: Association of C4B deficiency (C4B*Q0) with erythema nodosum in leprosy ..- Source: s.l; s.n; 1993. 4 p. tab. Descriptors: COMPLEMENTO 4B COMPLEMENTO 4B PROPERDINA FATOR B ERITEMA NODOSO ERITEMA NODOSO FREQUENCIA DOS GENES HANSENIASE HANSENIASE COMPLEXO PRINCIPAL DE HISTOCOMPATIBILIDADE Location: BR191.1; 06936/s

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Id: 9800 Author: Schlesinger, Larry S; Horwitz, Marcus A Title: A role for natural antibody in the pathogenesis of leprosy: antibody in nonimmune serum mediates C3 fixation to the Mycobacterium leprae surface and hence phagocytosis by human mononuclear phagocytes ..- Source: s.l; s.n; 1994. 10 p. ilus, tab, graf. Descriptors: HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE ANTICORPOS ANTICORPOS ANTIBACTÉRIAS COMPLEMENTO 1Q COMPLEMENTO 3 TESTES DE FIXAÇAO DE COMPLEMENTO VIA ALTERNATIVA DO COMPLEMENTO VIA CLASSICA DO COMPLEMENTO GLICOLIPIDIOS IMUNOGLOBULINAS LEUCOCITOS MONONUCLEARES FAGOCITOSE Location: BR191.1; 06748/s

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Id: 9480 Author: Schlesinger, Larry S; Horwitz, Marcus A Title: Phenolic glycolipid-1 of Mycobacterium leprae binds complement component C3 in serum and mediates phagocytosis by human monocytes ..- Source: s.l; s.n; 1991. 8 p. ilus, tab, graf. Descriptors: ANTIGENOS DE BACTÉRIAS COMPLEMENTO 3 ATIVAÇAO DE COMPLEMENTO GLICOLIPIDIOS MONOCITOS MYCOBACTERIUM LEPRAE FAGOCITOSE RECEPTORES DE COMPLEMENTO Limits: IN VITRO Location: BR191.1; 06336/s

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Id: 9199 Author: Cossermelli-Messina, W; Cossermelli, W Title: Humoral immunity in Hansen's disease ..- Source: Sao Paulo; s.n; 1995. 6 p. . Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE COMPLEXO ANTIGENO-ANTICORPO AUTO-ANTICORPOS COMPLEMENTO CRIOGLOBULINAS CAMUNDONGOS COELHOS Location: BR191.1; 06178/s

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Id: 7019 Author: Kliemann, Teresa A. E; Martinez, Ednir L. W; Irulegui, Ione; Souza, Zoia W. Telle de; Cavalcanti, Zelia Maria de O. Title: Conversion of the C3 component of complement in sera of hanseniasis patients. Source: Hansen. Int;8(1):5-8, jan. 1983. tab. Abstract: Os niveis de C3 total (C3 nativo mais seus produtos de degradacao) e o grau de conversao do C3 nativo em seus produtos de degradacao foram estudados em soros de pacientes V, T, I e de V com ENH. Soros de individuos normais foram tambem analisados, enquanto os niveis de C3 total nao diferiram significativamente entre os grupos, a conversao de C3 em seus produtos de degradacao foi significativamente maior nos soros de pacientes V e naqueles com ENH. A ativacao do sistema complemento e o envolvimento dos IC neste processo sao discutidos. (AU). Descriptors: HANSENIASE - COMPLEMENTO 3  ERITEMA NODOSO Electronic Medium: http://hansen.bvs.ilsl.br/textoc/hansenint/v01aov20/1983/PDF/v8n1/v8n1a01.pdf / EnPt Location: BR191.1

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Id: 3607 Author: Ramanathan, V. D; Sharma, Padmawati; Ramu, G; Sengupta, U Title: Reduced complement-mediated immune complex solubilization in leprosy patients ..- Source: s.l; s.n; 1985. 6 p. graf. Descriptors: HANSENIASE HANSENIASE COMPLEXO ANTIGENO-ANTICORPO COMPLEMENTO VIA ALTERNATIVA DO COMPLEMENTO VIA CLASSICA DO COMPLEMENTO COMPLEMENTO 3 SOROALBUMINA BOVINA SOLUBILIDADE FATORES DE TEMPO Location: BR191.1; 02445/s

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