Database : HANSEN Search on : INTERFERON TIPO II/BIOS [Subject descriptor] References found : 26 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 13942 Author: Maeda, Yumi; Gidoh, Masaichi; Ishii, Norihisa; Mukai, Chifumi; Makino, Masahiko Title: Assessment of cell mediated immunogenicity of Mycobacterium leprae-derived antigens ..- Source: s.l; s.n; 2003. 9 p. tab, graf. Abstract: The antigenicity of Mycobacterium leprae (M. leprae)-derived cell membrane fraction was examined using human dendritic cells (DCs). Immature DCs internalized and processed the cell membrane components, and expressed M. leprae-derived antigens (Ags) on their surface. The expression of MHC class II, CD86, and CD83 Ags on DCs and CD40 ligand (L)-associated IL-12 p70 production from DCs were up-regulated by the membrane Ags. Moreover these stimulated DCs induced significantly higher level of interferon-gamma (IFN-gamma) production by autologous CD4(+) and CD8(+) T cells than those pulsed with equivalent doses of live M. leprae or its cytosol fraction. Both subsets of T cells from tuberculoid leprosy patients also produced several fold more IFN-gamma than those from normal individuals. Furthermore, the intracellular perforin production in CD8(+) T cells was up-regulated in an Ag-dose dependent manner. These results suggest that M. leprae membrane Ags might be useful as the vaccinating agents against leprosy. (AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol ANTIGENOS DE SUPERFÍCIE/imunol LINFOCITOS T CD4-POSITIVOS/imunol LIGANTE A CD40/fisiol LINFOCITOS T CD8-POSITIVOS/imunol CELULAS DENDRITICAS/imunol INTERFERON TIPO II/bios INTERLEUCINA-12/bios TRANSFORMACAO LINFOCITICA GLICOPROTEINAS DE MEMBRANA/bios MYCOBACTERIUM LEPRAE/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 09083/s

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Id: 13429 Author: Nogueira, N; Kaplan, G; Levy, E; Sarno, E. N; Kushner, P; Granelli-Piperno, A; Vieira, L; Colomer Gould, V; Levis, W; Steinman, R Title: Defective gamma interferon production in leprosy ..- Source: s.l; s.n; December 01, 1983. 6 p. tab. Abstract: Antigen and mitogen-induced gamma interferon (gamma-IFN) production was studied in peripheral blood mononuclear cells from 34 leprosy patients. 17 of 18 lepromatous leprosy and borderline lepromatous patients (LL and BL) failed to release gamma-IFN in response to specific antigen (Mycobacterium leprae) and displayed reduced responses to mitogen (concanavalin A) stimulation. In contrast, cells from six tuberculoid and borderline tuberculoid patients (TT and BT) produced considerable levels of gamma-IFN under the same experimental conditions. Normal controls failed to respond to M. leprae and most displayed good responses to concanavalin A. Mid-borderline patients (BB) showed intermediate levels of gamma-IFN release. gamma-IFN release by lepromatous patients could be partially restored with purified interleukin 2 and M. leprae antigen but not with interleukin 2 alone.(AU). Descriptors: HANSENIASE/imunol INTERFERON TIPO II/bios MYCOBACTERIUM LEPRAE/imunol ANTIGENOS DE BACTERIAS/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 01387/s

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Id: 12279 Author: Kim, Jenny; Uyemura, Koichi; Van Dyke, Melissa K; Legaspi, Annaliza J; Rea, Thomas H; Shuai, Ke; Modlin, Robert L Title: A role for IL-12 receptor expression and signal transduction in host defense in leprosy ..- Source: s.l; s.n; 2001. 8 p. graf. Descriptors: ANTIGENOS DE BACTÉRIAS PROTEINAS DE LIGAÇAO DE DNA TOLERANCIA IMUNOLOGICA IMUNIDADE CELULAR INTERFERON TIPO II INTERLEUCINA-12 INTERLEUCINA-12 HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE TRANSFORMAÇAO LINFOCITICA MYCOBACTERIUM LEPRAE FOSFORILAÇAO RECEPTORES DA INTERLEUCINA RECEPTORES DA INTERLEUCINA TRANSDUÇAO DE SINAL LINFOCITOS T TRANSATIVADORES CELULAS CULTIVADAS Limits: ESTUDO COMPARATIVO Location: BR191.1; 08631/s

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Id: 12245 Author: Geluk, Annemieke; Van Meijgaarden, Krista E; Franken, Kees L. M. C; Subronto, Yanri W; Wieles, Brigitte; Arend, Sandra M; Sampaio, Elizabeth P; Boer, Tjitske de; Faber, William R; Naafs, Ben; Ottenhoff, Tom H. M Title: Identification and characterization of the ESAT-6 homologue of mycobacterium leprae and T-cell cross-reactivity with mycobacterium tuberculosis ..- Source: s.l; s.n; May 2002. 5 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS REAÇOES CRUZADAS INTERFERON TIPO II HANSENIASE DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS LINFOCITOS T TUBERCULOSE Location: BR191.1; 08648/s

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Id: 12240 Author: Brahmbhatt, S; Hussain, R; Zafar, S; Dawood, G; Ottenhoff, T. H. M; Drijfhout, J. W; Bothamley, G; Smith, S; Lopez, F. V; Dockrell, H. M Title: Human T cell responses to peptides of the mycobacterium leprae 45-kD serine-rich antigen ..- Source: s.l; s.n; 2002. 9 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS LINHAGEM CELULAR EPITOPOS DE LINFOCITO T EPITOPOS DE LINFOCITO T REINO UNIDO ANTIGENOS HLA-DR EPITOPOS IMUNODOMINANTES EPITOPOS IMUNODOMINANTES INTERFERON TIPO II HANSENIASE TUBERCULOIDE PAQUISTAO PEPTIDIOS HOMOLOGIA DE SEQUENCIA DE AMINOACIDOS SERINA LINFOCITOS T TUBERCULOSE PULMONAR Células Cultivadas Limits: ESTUDO COMPARATIVO Location: BR191.1; 08643/s

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Id: 12234 Author: Ohyama, Hideki; Matsushita, Sho; Nishimura, Fusanori; Kato, Nahoko; Hatano, Kentaro; Takashiba, Shogo; Murayama, Yoji Title: T cell responses to major membrane protein II (MMP II) of mycobacterium leprae are restricted by HLA-DR molecules in patients with leprosy ..- Source: s.l; s.n; 2001. 8 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS PROTEINAS DE BACTÉRIAS ANTIGENOS HLA-DR INTERFERON TIPO II INTERLEUCINA-5 HANSENIASE DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE LINFOCITOS T Location: BR191.1; 08636/s

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Id: 11759 Author: Brahmbhatt, S; Hussain, R; Zafar, S; Dawood, G; Ottenhoff, Tom H. M; Drijfhout, J. W; Bothamley, G; Smith, S; Lopez, F. V; Dockrell, H. M Title: Human T cell responses to peptides of the Mycobacterium leprae 45-KD serine-rich antigen ..- Source: s.l; s.n; 2002. 9 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS LINHAGEM CELULAR EPITOPOS DE LINFOCITO T EPITOPOS DE LINFOCITO T REINO UNIDO ANTIGENOS HLA-DR EPITOPOS IMUNODOMINANTES EPITOPOS IMUNODOMINANTES INTERFERON TIPO II HANSENIASE TUBERCULOIDE DADOS DE SEQUENCIA MOLECULAR PESO MOLECULAR MYCOBACTERIUM LEPRAE PAQUISTAO PEPTIDIOS HOMOLOGIA DE SEQUENCIA DE AMINOACIDOS SERINA LINFOCITOS T TUBERCULOSE PULMONAR CELULAS CULTIVADAS Limits: ESTUDO COMPARATIVO Location: BR191.1; 08519/s

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Id: 11703 Author: Moraes, Milton O; Sarno, Euzenir N; Teles, Rosane M. B; Almeida, Alexandre S; Saraiva, Bruno C. C; Nery, José A. C; Sampaio, Elizabeth P Title: Anti-inflammatory drugs block cytokine mRNA accumulation in the skin and improve the clinical condition of reactional leprosy patients ..- Source: s.l; s.n; 2000. 6 p. tab. Descriptors: HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA ANTIINFLAMATORIOS ANTIINFLAMATORIOS BIOPSIA CITOCINAS CITOCINAS ERITEMA NODOSO ERITEMA NODOSO EXPRESSAO GENICA INTERFERON TIPO II INTERLEUCINA-4 REAÇAO EM CADEIA POR POLIMERASE PELE PELE FATOR DE NECROSE DE TUMOR Location: BR191.1; 08424/s

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Id: 11700 Author: Geluk, Annemieke; Meijgarden, E. van; Franken, Kees L. M. C; Subronto, Yanri W; Wieles, Brigitte; Arend, Sandra M; Sampaio, Elizabeth P; Boer, Tijitske de; Faber, William R; Naafs, Ben; Ottenhof, Tom H. M Title: Identification and characterization of the ESAT-6 homologue of Mycobacterium leprae and T-cell cross-reactivity with Mycobacterium tuberculosis ..- Source: s.l; s.n; 2002. 5 p. tab, graf. Descriptors: HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS LINFOCITOS T TUBERCULOSE SEQUENCIA DE AMINOACIDOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS REAÇOES CRUZADAS INTERFERON TIPO II Location: BR191.1; 08444/s

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Id: 11594 Author: Martin, E; Roche, P. W; Triccas, J. A; Britton, W. J Title: DNA encoding a single mycobacterial antigen protects against leprosy infection ..- Source: s.l; s.n; 2001. 6 p. tab. Descriptors: ANTIGENOS DE BACTÉRIAS VACINA BCG VACINAS BACTERIANAS VACINAS BACTERIANAS VACINAS BACTERIANAS SEQUENCIA DE BASES PRIMERS DO DNA DNA BACTERIANO DNA BACTERIANO INTERFERON TIPO II HANSENIASE HANSENIASE HANSENIASE CAMUNDONGOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE LINFOCITOS T VACINAS DE DNA/GE/IM/*PD Limits: ANIMAL Location: BR191.1; 08417/s

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Id: 11478 Author: afutis-Morris, Mary; Guillén-Vargas, Cecilia M; Navarro-Fierros, Sérgio; Alfaro-Bustamante, Fernando; Zaitzeva-Petrovna, Galina; Daneri-Navarro, Adrian; Santoscoy-Tovar, Luis; Armendariz-Borunda, Juan Title: Addition of anti-CD28 antibodies restores PBMC proliferation and IFN-gamma production in lepromatous leprosy patients ..- Source: s.l; s.n; 1999. 7 p. graf. Descriptors: HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA ANTICORPOS MONOCLONAIS ANTIGENOS CD28 ANTIGENOS CD80 LINFOCITOS B DIVISAO CELULAR INTERFERON TIPO II LEUCOCITOS MONONUCLEARES LEUCOCITOS MONONUCLEARES FITOHEMAGLUTININAS LINFOCITOS T Location: BR191.1; 08357/s

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Id: 11322 Author: Naito, Mariko; Matsuoka, Masanori; Ohara, Naoya; Nomaguchi, Hiroko; Yamada, Takeshi Title: The antigen 85 complex vaccine against experimental mycobacterium leprae infection in mice ..- Source: s.l; s.n; 2000. 4 p. tab, graf. Descriptors: ANTIGENOS DE BACTÉRIAS VACINAS BACTERIANAS INTERFERON TIPO II HANSENIASE CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C MYCOBACTERIUM LEPRAE BAÇO BAÇO CAMUNDONGOS NUS Limits: ANIMAL Location: BR191.1; 07261/s

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Id: 10949 Author: Lima, M. C. B. S; Pereira, G. M. B; Rumjanek, F. D; Gomes, H. M; Duppre, N; Sampaio, E. P; Alvim, I. M. P; Nery, J. A. C; Sarno, E. N; Pessolani, M. C. V Title: Immunological cytokine correlates of protective immunity and pathogenesis in leprosy ..- Source: s.l; s.n; 2000. 10 p. tab, graf. Descriptors: ADOLESCENCIA VACINA BCG CRIANÇA IMUNIDADE INTERFERON TIPO II INTERLEUCINA-10 HANSENIASE HANSENIASE HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE TRANSFORMAÇAO LINFOCITICA MYCOBACTERIUM LEPRAE TESTES CUTANEOS LINFOCITOS T VACINAÇAO FATOR DE NECROSE TUMORAL/*BI Location: BR191.1; 07459/s

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Id: 10338 Author: Mesret, Yohannes; Reed, Allen H; Howe, Rawleigh Title: Proliferative responses of T cells from the skin and nerve lesions of leprosy patients ..- Source: s.l; s.n; 1995. 10 p. tab, graf. Descriptors: ANTIGENOS CD28 ANTIGENOS CD3 ANTIGENOS CD45 INTERFERON TIPO II RECEPTORES DA INTERLEUCINA 2 INTERLEUCINA-2 INTERLEUCINA-4 HANSENIASE HANSENIASE TRANSFORMAÇAO LINFOCITICA TRANSFORMAÇAO LINFOCITICA MITOGENOS NERVOS PERIFÉRICOS FITOHEMAGLUTININAS PELE LINFOCITOS T LINFOCITOS T CELULAS CULTIVADAS Location: BR191.1; 07189/s

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Id: 10309 Author: Barral-Netto, M; Santos, S; Santos, I; von Sohsten, R; Bittencourt, A. L; Carvalho, E. M; Barral, A; Waters, M Title: Immunochemotherapy with interferon-y and multidrug therapy for multibacillary leprosy ..- Source: s.l; s.n; 1999. 7 p. tab, graf. Descriptors: ADOLESCENCIA ANTICORPOS ANTIBACTÉRIAS CRIANÇA CLOFAZIMINA DAPSONA QUIMIOTERAPIA COMBINADA INTERFERON TIPO II LEPROSTATICOS HANSENIASE HANSENIASE TRANSFORMAÇAO LINFOCITICA RIFAMPINA PELE INTERFERON GAMA RECOMBINANTE/*TU NEOPTERINA/AN Location: BR191.1; 07414/s

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Id: 10308 Author: Stewart, G. R; Boussinesq, M; Coulson, T; Elson, L; Nutman, T; Bradley, J. E Title: Onchocerciasis modulates the immune response to mycobacterial antigens ..- Source: s.l; s.n; 1999. 7 p. graf. Descriptors: ADOLESCENCIA ANTIGENOS DE HELMINTOS CRIANÇA PRÉ-ESCOLAR INTERFERON TIPO II INTERLEUCINA-4 HANSENIASE HANSENIASE LEUCOCITOS MONONUCLEARES MYCOBACTERIUM LEPRAE MYCOBACTERIUM TUBERCULOSIS ONCHOCERCA VOLVULUS ONCOCERCIASE ONCOCERCIASE TUBERCULINA TUBERCULOSE TUBERCULOSE CELULAS CULTIVADAS Limits: ANIMAL Location: BR191.1; 07413/s

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Id: 10298 Author: Weir, R. E; Brennan, P. J; Butlin, C. R; Dockrell, H. M Title: Use of a whole blood assay to evaluate in vitro T cell responses to new leprosy skin test antigens in leprosy patients and healthy subjects ..- Source: s.l; s.n; 1999. 7 p. tab. Descriptors: ANTIGENOS DE BACTÉRIAS PROTEINAS DE BACTÉRIAS INTERFERON TIPO II HANSENIASE HANSENIASE TRANSFORMAÇAO LINFOCITICA PESO MOLECULAR MYCOBACTERIUM LEPRAE TESTES CUTANEOS ESTERILIZAÇAO LINFOCITOS T Location: BR191.1; 07400/s

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Id: 10245 Author: Sieling, Peter A; Wang, Xiao-Hong; Gately, Maurice K; Oliveros, Jennifer L; McHugh, Teresa; Barnes, Peter F; Wolf, Stanley F; Golkar, Linda; Yamamura, Masahiro; Yogi, Yasuko; Uyemura, Koichi; Rea, Thomas H; Modlin, Robert L Title: IL-12 regulates T helper type 1 cytokine responses in human infectious disease ..- Source: s.l; s.n; 1994. 9 p. ilus, graf. Descriptors: SEQUENCIA DE BASES LINFOCITOS T CD8-POSITIVOS PRIMERS DO DNA EXPRESSAO GENICA INTERFERON TIPO II INTERLEUCINA-10 INTERLEUCINA-12 INTERLEUCINA-4 INTERLEUCINA-4 HANSENIASE TRANSFORMAÇAO LINFOCITICA DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE RNA MENSAGEIRO SUB-POPULAÇOES DE LINFOCITOS T CÉLULAS TH1 Location: BR191.1; 06955/s

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Id: 10125 Author: Sreenivasan, P; Misra, P. S; Wilfred, D; Nath, I Title: Lepromatous leprosy patients show T helper 1-like cytokine profile with differential expression of interleukin-10 during type 1 and 2 reactions ..- Source: s.l; s.n; 1998. 8 p. ilus, tab. Descriptors: DOENÇA AGUDA ELISA ERITEMA NODOSO INTERFERON TIPO II INTERFERON TIPO II INTERFERON TIPO II INTERLEUCINA-10 INTERLEUCINA-10 INTERLEUCINA-10 INTERLEUCINA-4 INTERLEUCINA-4 INTERLEUCINA-4 HANSENIASE LEPROMATOSA MONOCITOS RNA MENSAGEIRO PELE CÉLULAS TH1 CELULAS CULTIVADAS REACAO EM CADEIA POR POLIMERASE VIA TRANSCRIPTASE Location: BR191.1; 07066/s

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Id: 9926 Author: Hans-Dieter, Flad; Gercken, Jens; Hubner, Lorenz; Schluter, Carsten; Pryjma, Juliusz; Ernst, Martin Title: Cytokines in mycobacterial infections: in vitro and ex vivo studies ..- Source: s.l; s.n; 1995. 6 p. ilus, tab, graf. Descriptors: HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA MYCOBACTERIUM TUBERCULOSIS MICOBACTERIOSE CÉLULAS QUE APRESENTAM ANTIGENOS CÉLULAS QUE APRESENTAM ANTIGENOS CÉLULAS QUE APRESENTAM ANTIGENOS BIOPSIA CITOCINAS DOWN-REGULATION (FISIOLOGIA) ANTIGENOS HLA-DR PEROXIDO DE HIDROGENIO INTERFERON TIPO II RECEPTORES DA INTERLEUCINA-1 MONOCITOS MONOCITOS MONOCITOS PELE PELE FATOR DE NECROSE DE TUMOR Location: BR191.1; 06865/s

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