Database : HANSEN Search on : MACROFAGOS/FISIOL [Subject descriptor] References found : 10 [refine] Displaying: 1 .. 10   in format [Detailed]

page 1 de 1

1 / 10

HANSEN

select to print Texto Completo-en

Id: 19600 Author: Yamagami, A. Title: Aggregation phenomenon of cultivated blood macrophages isolated from leprosy patients. Source: Int. J. Lep;57(4):873-874, dec. 1989. . Descriptors: Hanseníase/imunol Hanseníase/terap Macrófagos/imunol Macrófagos/fisiol Limits: Humanos Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n4/v57n4cor05.pdf / en Location: Br191.1

2 / 10

HANSEN

select to print Texto Completo-en

Id: 19308 Author: Shimizu, Toshiaki; Tomioka, Haruaki; Matsuoka, Masanori; Sano, Chiaki. Title: Profiles of the mRNA expression by macrophages infected with mycobacterium leprae and mycobacterium avium complex. Source: Int. J. Lepr;70(4):250-259, Dec., 2002. ilus, tab. Abstract: In the present study, we examined profiles of the interaction of Mycobacterium leprae and Mycobacterium avium complex (MAC) with murine peritoneal macrophages (M phi s) in terms of up-regulation of M phi expression of proinflammatory and immunosuppressing cytolines (CKs) after infection. First, the reverse transcription polymerase chain reaction (RT-PCR) assay revealed that both MAC and M. leprae infections up-regulated M phi mRNA expression IL-12, TNF-alpha, IL-10, and transformating growth factor-beta (TGF-beta), except that M. leprae-infected M phi s showed no increase in the IL-12 mRNA expression. Second, the RT-PCR assay also showed some differences between M. leprae- and MAC-infected M phi s with respect to the modes of IL-10 and inducible nitric oxide synthase (iNOS) mRNA expression. That is MAC, but not M. leprae, infection caused a prolonged increase in the expression of IL-10 and iNOS mRNAs. Third, a ribonuclease protection assay revealed that M phi s co-infected with MAC and M. leprae showed the Il-12, TNF-alpha and IL-10 mRNA expression in an intermediate mode of those of M phi s infected with either M. leprae or MAC alone. This implies that the CK expression of M. leprae-infected M phi s may be modified by co-infection with MAC. These findings may suggest differential interactions of M. leprae and MAC organisms with murine peritoneal M phi s in terms of the activation of signal transduction pathways for expression of some kinds of immunoregulatory cytokines and immunoprotective enzymes.(AU)^ien. Descriptors: RNA/genet RNA/imunol Macrófagos/citol Macrófagos/fisiol Mycobacterium avium/citol Mycobacterium avium/genet Mycobacterium leprae/citol Mycobacterium leprae/genet Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/2002/pdf/v70n4/v70n4a02.pdf / en Location: BR191.1

3 / 10

HANSEN

select to print

Id: 18431 Author: Sunderkotter, Cord H; Tomimori-Yamashita, Jane; Nix, Verena; Maeda, Solange M; Sindrilaru, Anca; Mariano, Mario; Sorg, Clemens; Roth, Johannes Title: High expression of myeloid-related proteins 8 and 14 characterizes an inflammatory active but ineffective response of macrophages during leprosy ..- Source: s.l; s.n; 2004. 9 p. ilus, tab, graf. Abstract: Macrophages are decisive cells for the course of leprosy as they phagocytose Mycobacterium leprae and have the potential to influence the specific immune response. Expression and release of the myeloid-related protein (MRP) 8 and MRP14 (S100A8 and S100A9) characterize a proinflammatory subtype of macrophage that is prominent in, for example, murine infection with lack of a T helper 1 cell response and in certain highly active chronic inflammations of mice and humans. We investigated cutaneous biopsies of the different forms of leprosy (41 untreated patients) including leprosy reaction type 1 (reversal reaction) and type 2 (erythema nodosum leprosum) (n=18) for expression of MRP8 and MRP14 by subtupes of macrophages. Concomitantly we determined serum levels of MRP8 and MRP14 by sandwich enzyme-linked immunosorbent assay. Expression of MRP8 and MRP14 by CD68-positive macrophages was low in tuberculoid leprosy and rose significantly in borderline tuberculoid leprosy and especially in multibacillary forms, there being expressed by mycobacteria-loaded foam cells. A significant rise of MRP8 and MRP14 expression also occurred in lepra reactions compared to the corresponding non-reactional forms. In type 2 reactions this additional increased was associated with a significant elevation of serum levels. In type 1 it was associated with expression of MRP8 and MRP14 by epitheloid and giant cells, which so far were considered not to express both proteins. In conclusion, we present evidence taht the two prominent proteins MRP8 and MRP14 can be re-expressed in vivo by tissue macrophages in chronic infection, that their increased expression is characteristic for a macrophage subtype associated with high inflammatory but low antimycobacterial activity in the absence of a T helper 1 response, and that their significant rise in serum during erythema nodosum leprosum bears diagnostic and pathophysiological relevance. (AU). Descriptors: MYCOBACTERIUM LEPRAE/imunol CELULAS MIELOIDES/citol CELULAS MIELOIDES/imunol - MACROFAGOS/citol  MACROFAGOS/imunol  MACROFAGOS/microbiol  MACROFAGOS/fisiol Limits: HUMANO Location: BR191.1; 00690/s

4 / 10

HANSEN

select to print

Id: 13479 Author: Shirahama, Tsuranobu; Cohen, Alan S Title: Lysosomal breakdown of amyloid fibrils by macrophages ..- Source: s.l; s.n; jun. 1971. 26 p. ilus, graf. Abstract: Mouse peritoneal macrophages incubated with isolated human amyloid fibrils for varying periods of time up to 24 hours were studies by electron microscopy, and by electron microscopic cytochemistry for demonstration of acid phosphatase activity. The sequential changes in cytoplasmatic vacuoles in macrophages containing the amyloid fibrils and related material were analyzed and compared with those in controls and with direct enzymatic digestion of amyloid fibrils. the results suggest that the lysosome into amorphous, granular or finely filamentous material and absorbed, leaving undigested material as membranous or myeling the lysosomal enzymes into the amyloid-phagosome or the amyloid-phagolysosome was studied and interpreted as showing (1) fusion of primary lysosome (s) with the phagocytic vacuole, (2) autophagy of primary lysosome(s) into the heterophagic vacuole, and (3) transport of the enzymes into the phagocytic vacuole durectly from the Golgi associated vesicles or smooth endoplasmatic reticulum.(AU). Descriptors: APARELHO DE GOLGI/fisiol FOSFATASE ACIDA/anal AMILOIDE/metab CITOPLASMA/fisiol RETICULO ENDOPLASMATICO/fisiol MACROFAGOS/enzimol MACROFAGOS/patol MACROFAGOS/fisiol PERITÔNIO/citol Limits: HUMANO ANIMAL CAMUNDONGOS Electronic Medium: http://www.ilsl.br Location: BR191.1; 00056/s

5 / 10

HANSEN

select to print

Id: 12244 Author: Rambukkana, Anura; Zanazzi, George; Tapinos, Nikos; Salzer, James L Title: Contact-dependent demyelination by mycobacterium leprae in the absence of immune cells ..- Source: s.l; s.n; May 2002. 5 p. ilus, graf. Descriptors: APOPTOSE AXONIOS AXONIOS LINFOCITOS B ADERENCIA BACTERIANA DIVISAO CELULAR COCULTURA DOENÇAS DESMIELINIZANTES GANGLIOS ESPINHAIS GENES RAG-1 GLICOLIPIDIOS HANSENIASE HANSENIASE HANSENIASE HANSENIASE MACROFAGOS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS C57BL CAMUNDONGOS KNOCKOUT MUTAÇAO MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE BAINHA DE MIELINA BAINHA DE MIELINA DEGENERAÇAO NEURAL FIBRAS NERVOSAS MIELINIZADAS NEURONIOS CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN NERVO CIATICO NERVO CIATICO LINFOCITOS T CULTURA DE TECIDO Limits: ANIMAL Location: BR191.1; 08647/s

6 / 10

HANSEN

select to print

Id: 11749 Author: Rambukkana, Amura; Zanazzi, George; Tapinos, Nikos; Salzer, James L Title: Contact-dependent demyelination by Mycobacterium leprae in the absence of immune cells ..- Source: s.l; s.n; 2002. 5 p. ilus. Descriptors: HANSENIASE HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE AXONIOS AXONIOS ADERENCIA BACTERIANA DIVISAO CELULAR COCULTURA DOENÇAS DESMIELINIZANTES GANGLIOS ESPINHAIS GENES RAG-1 GLICOLIPIDIOS MACROFAGOS MUTAÇAO BAINHA DE MIELINA BAINHA DE MIELINA DEGENERAÇAO NEURAL - FIBRAS NERVOSAS MIELINIZADAS  NEURONIOS  CÉLULAS DE SCHWANN  CÉLULAS DE SCHWANN  NERVO CIATICO  NERVO CIATICO  LINFOCITOS T  CULTURA DE TECIDO Location: BR191.1; 08525/s

7 / 10

HANSEN

select to print

Id: 10270 Author: Singh, Neeta; Birdi, Tannaz J; Antia, Noshir H Title: Differential in vitro modulation of schwann cell proliferation by mycobacterium leprae and macrophages in the murine strains, Swiss white and C57BI/6 ..- Source: s.l; s.n; 1998. 10 p. tab, graf. Descriptors: DIVISAO CELULAR COCULTURA HANSENIASE MACROFAGOS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS C57BL MYCOBACTERIUM LEPRAE CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN CELULAS CULTIVADAS Limits: ANIMAL Location: BR191.1; 07165/s

8 / 10

HANSEN

select to print

Id: 10105 Author: Moura, A. C. N; Modolell, M; Mariano, M Title: Down-regulatory effect of Mycobacterium leprae cell wall lipids on phagocytosis, oxidative respiratory burst and tumour cell killing by mouse bone marrow derived macrophages ..- Source: s.l; s.n; 1997. 6 p. ilus, tab, graf. Descriptors: PAREDE CELULAR DEPRESSAO QUIMICA HANSENIASE LIPIDIOS LIPIDIOS LIPOSSOMOS ATIVAÇAO DE MACROFAGOS MACROFAGOS MACROFAGOS MACROFAGOS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C CAMUNDONGOS ENDOGAMICOS C57BL MYCOBACTERIUM LEPRAE FAGOCITOSE EXPLOSAO RESPIRATORIA SUPEROXIDOS CELULAS DA MEDULA OSSEA/*DE/PH CELULAS CULTIVADAS Limits: ANIMAL Location: BR191.1; 07046/s

9 / 10

HANSEN

select to print

Id: 9961 Author: Schurr, Erwin; Malo, Danielle; Radzioch, Danuta; Buschman, Ellen; Morgan, Kenneth; Gros, Philippe; Skamene, Emil Title: Genetic control of innate resistance to mycobacterial infections ..- Source: s.l; s.n; 1991. 4 p. ilus, graf. Descriptors: MAPEAMENTO CROMOSSOMICO REGULAÇAO DA EXPRESSAO GENICA NO DESENVOLVIMENTO MARCADORES GENÉTICOS IMUNIDADE NATURAL ATIVAÇAO DE MACROFAGOS MACROFAGOS CAMUNDONGOS CAMUNDONGOS CAMUNDONGOS MICOBACTERIOSE MICOBACTERIOSE FENOTIPO TUBERCULOSE TUBERCULOSE Location: BR191.1; 06539/s

10 / 10

HANSEN

select to print

Id: 9630 Author: Parida, S. K; Grau, G. E Title: Role of TNF in immunopathology of leprosy ..- Source: s.l; s.n; 1993. 9 p. ilus. Descriptors: CITOCINAS HANSENIASE HANSENIASE HANSENIASE HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA MACACA MULATTA MACROFAGOS CAMUNDONGOS CAMUNDONGOS DE CEPAS ENDOGAMICAS TUBERCULOMA TUBERCULOMA FATOR DE NECROSE TUMORAL/*PH Limits: ANIMAL Location: BR191.1; 06562/s

---

page 1 de 1

Refine the search

Database : HANSEN

Advanced form

Search for : Free form

		Search	in field
1			WordsTitle wordsAbstract wordsAuthorInstitutional authorSubject descriptorLimitsLanguageCountry, year publicationJournalType of literatureBibliographic levelMonography in seriesPublication typeConferenceUnique identifierLocationElectronic supportEntry dateRecord type
2	and or and not		WordsTitle wordsAbstract wordsAuthorInstitutional authorSubject descriptorLimitsLanguageCountry, year publicationJournalType of literatureBibliographic levelMonography in seriesPublication typeConferenceUnique identifierLocationElectronic supportEntry dateRecord type
3	and or and not		WordsTitle wordsAbstract wordsAuthorInstitutional authorSubject descriptorLimitsLanguageCountry, year publicationJournalType of literatureBibliographic levelMonography in seriesPublication typeConferenceUnique identifierLocationElectronic supportEntry dateRecord type

Search engine: iAH powered by WWWISIS

IAH - © BIREME/PAHO/WHO Latin American and Caribbean Center on Health Sciences Information