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Id: 17881 Author: Silva, Eliane Aparecida; Rúbio, Eliana Milanesi; Ura, Somei. Title: Sistema sanguíneo Lewis em pacientes hansenianos / Lewis blood group system in leprosy patients Source: Hansen. int;25(2):f115l120, jul.-dez. 2000. tab. Abstract: No presente estudo avaliamos a distribuiçäo fenotípica do grupo sanguíneo Lewis na saliva e nos eritrócitos de pacientes hansenianos. Foram analisados 47 pacientes e 40 indivíduos controles quanto a presença de antígenos ABH bem como dos antígenos Lewis nos eritrócitos e na saliva, pela reaçäo de aglutinaçäo e inibiçäo de aglutinaçäo. As frequências dos fenótipos Lewis e secretor/näo nesses pacientes e no grupo controle foram: Le(a- b+) = 29,8(por cento) 62,5(por cento); Le(a+ b-) = 25,5(por cento) 7,5(por cento); Le(a- b-) = 44,7(por cento) 30,0(por cento); secretor = 59,5(por cento) e näo secretor = 40,5(por cento) 15(por cento). Em análise de X2 encontramos diferença significativa tanto para o fenótipo Lewis como para o fenótipo secretor, em relaçäo ao grupo controle respectivamente: X2 = 10,46; GL = 2; p=0,005 e X2 = 5,64; GL = 1; p = 0,018. Da mesma forma, o teste Z de proporçöes foi realizado obtendo resultados significativos para os fenótipos Le (a + b-) e Le (a- b+), que foram respectivamente: Z = 2,219; p = 0,027 e Z = 3,058; p = 0,002. Os resultados indicam que o fenótipo Le (a+ b-) parece estar associado à suscetibilidade à hanseníase e fenótipo secretor com proteçäo. Discute-se que a presença de Le na saliva pode inibir a aderência do M. Leprae às células da mucosa, protegendo assim contra infecçäo.(AU). Descriptors: HANSENIASE/sangue HANSENIASE/imunol HANSENIASE/fisiopatol SISTEMA DO GRUPO SANGUINEO DE LEWIS/anal SISTEMA DO GRUPO SANGUINEO DE LEWIS/uso diag SISTEMA DO GRUPO SANGUINEO DE LEWIS/uso terap MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM LEPRAE/fisiol - FENOTIPO Limits: ESTUDO COMPARATIVO HUMANO Electronic Medium: http://hansen.bvs.ilsl.br/textoc/hansenint/v21aov29/2000/PDF/v25n2/v25n02a01.pdf / pt Location: BR191.1

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Id: 13965 Author: Hoal, Eileen G Title: Human genetic susceptibility to tuberculosis and other mycobacterial diseases ..- Source: s.l; s.n; 2002. 5 p. . Abstract: The existence of a genetic component in mycobacterial disease susceptibility is no longer in doubt and the investigations now being conducted aim to determine which genes are involved, to what extent, and in which disease phenotype they are relevant. In certain rare instances of susceptibility to poorly pathogenic mycobacteria, the genetic component is clear. The approaches employed to elucidate common disease susceptibility include linkage studies, particularly genome-wide linkage analysis of both tuberculosis and leprosy, and association studies. A number of candidate genes have shown association with tuberculosis, and in many cases, on replication of the study, association has been confirmed in a disparate population, indicating the wider importance of the gene in the disease process. In other instances, associations appear to be particular to a population or a subtype of disease. (AU). Descriptors: PREDISPOSICAO GENETICA PARA DOENÇA LIGACAO (GENETICA) GENOTIPO MYCOBACTERIUM TUBERCULOSIS/patogen TUBERCULOSE/epidemiol TUBERCULOSE/genet FENOTIPO Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09058/s

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Id: 13659 Author: Mira, M. T; Alcais, A; Pietrantonio, T. di; Thuc, N. V; Phuong, M. C; Abel, L; Schurr, E Title: Segregation of HLA/TNF region is linked to leprosy clinical spectrum in families displaying mixed leprosy subtypes ..- Source: s.l; s.n; 2003. 7 p. ilus, tab, graf. Abstract: Each year an estimated 600000 new leprosy cases are diagnosed worldwide. The spectrum of the disease varies widely from limited tuberculoid forms to extensive lepromatous forms. A measure of the risk to develop lepromatous forms of leprosy is provided by the extent of skin reactivity to lepromin (Mitsuda reaction). To address a postulated oligogenic control of leprosy pathogenesis, we investigated in the present study linkage of leprosy susceptibility, leprosy clinical subtypes, and extent of the Mitsuda reaction to six chromosomal regions carrying known or suspected leprosy susceptibility loci. The only significant result obtained was linkage of leprosy clinical subtype to the HLA/TNF region on human chromosome 6p21 (P(corrected)=0.00126). In addition, we established that within the same family different HLA/TNF haplotypes segregate into patients with different leprosy subtypes directly demonstrating the importance of this genome region for the control of clinical leprosy presentation. (AU). Descriptors: CROMOSSOMOS HUMANOS PAR 6/genet PREDISPOSICAO GENETICA PARA DOENÇA GENOTIPO HANSENIASE/clas HANSENIASE/genet ANTIGENOS HLA/genet LIGACAO (GENETICA)/genet FATOR DE NECROSE TUMORAL/genet - FENOTIPO  LINHAGEM Limits: HUMANO MASCULINO FEMININO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09137/s

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Id: 13635 Author: Hoal, Eileen G Title: Human genetic susceptibility to tuberculosis and other mycobacterial diseases ..- Source: s.l; s.n; 2002. 5 p. . Abstract: The existence of a genetic component in mycobacterial disease susceptibility is no longer in doubt and the investigations now being conducted aim to determine which genes are involved, to what extent, and in which disease phenotype they are relevant. In certain rare instances of susceptibility to poorly pathogenic mycobacteria, the genetic component is clear. The approaches employed to elucidate common disease susceptibility include linkage studies, particularly genome-wide linkage analysis of both tuberculosis and leprosy, and association studies. A number of candidate genes have shown association with tuberculosis, and in many cases, on replication of the study, association has been confirmed in a disparate population, indicating the wider importance of the gene in the disease process. In other instances, associations appear to be particular to a population or a subtype of disease.(AU). Descriptors: PREDISPOSICAO GENETICA PARA DOENÇA GENOTIPO LIGACAO (GENETICA) MYCOBACTERIUM TUBERCULOSIS/patogen FENOTIPO TUBERCULOSE/epidemiol TUBERCULOSE/genet Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09044/s

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Id: 13534 Author: Alcaïs, A; Sanchez, F. O; Thuc, N. V; Lap, V. D; Oberti, J; Lagrange, P. H; Schurr, E; Abel, L Title: Granulomatous reaction to intradermal injection of lepromin (Mitsuda reaction) is linked to the human NRAMP1 gene in Vietnamese leprosy ..- Source: s.l; s.n; 2000. 7 p. tab, graf. Abstract: The Mitsuda test, which measures the specific immune response against intradermally injected lepromin, has a high prognostic value for susceptibility or resistance to the lepromatous form of leprosy. A sib-pair linkage analysis between the Mitsuda response and the NRAMP1 gene was done among 20 nuclear families with leprosy (totaling 118 sibs) from Ho Chi Minh City, Vietnam. All family subjects were genotyped for several intragenic and flanking NRAMP1 markers, leading to the definition of a fully informative NRAMP1 haplotype. Significant linkage was observed between NRAMP1 and Mitsuda reaction when considered either as a quantitative (P<.002) or as a categorical (P=.001) trait. Separate analyses among healthy and affected sibs showed evidence for linkage in both subsamples, indicating that linkage between the Mitsuda reaction and NRAMP1 is independent of leprosy status. These results support the view that NRAMP1 plays a regulatory role for the development of acquired antimycobacterial immune responses as determined by in vivo Mitsuda test reaction. (AU). Descriptors: HANSENIASE/imunol ANTIGENO DE MITSUDA/imunol HANSENIASE VIRCHOWIANA/imunol HANSENIASE TUBERCULOIDE/imunol PELE/imunol VIETNA GRANULOMA CHINA/etnol - HAPLOTIPOS  IMUNIDADE NATURAL  INJECOES INTRADERMICAS  LINHAGEM  NUCLEO FAMILIAR  FENOTIPO  LINFOCITOS T AUXILIADORES-INDUTORES Limits: HUMANO MASCULINO FEMININO SUPPORT, NON-U.S. GOV'T Location: BR191.1; 08991/s

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Id: 13331 Author: Furukawa, F; Sekita, K; Hamashima, Y; Ozaki, M; Imamura, S Title: Evaluation of circulating immune complexes and antinuclear antibodies in japanese patients with leprosy ..- Source: s.l; s.n; 1983. 3 p. tab, graf. Abstract: In 79 patients with leprosy a significant increase of anti-extractable nuclear antigen (ENA) antibodies and circulating immune complexes (CIC) was found....(AU). Descriptors: HANSENIASE/imunol COMPLEXO ANTIGENO-ANTICORPO/anal ANTICORPOS ANTINUCLEARES/anal ANTICORPOS ANTINUCLEARES/genet - FENOTIPO  RADIOIMUNOENSAIO Electronic Medium: http://www.ilsl.br Location: BR191.1; 01236/s

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Id: 11078 Author: Shaw, Marie-Anne; Donaldson, I. J; Collins, A; Peacock, C. S; Lins-Lainson, Z; Shaw, J. J; Ramos, F; Silveira, F; Blackwell, J. M Title: Association and linkage of leprosy phenotypes with HLA class II and tumor necrosis factor genes ..- Source: s.l; s.n; 2001. 9 p. tab. Descriptors: HANSENIASE HANSENIASE GENES CLASSE II DO COMPLEXO DE HISTOCOMPATIBILIDADE (MHC) LIGAÇAO (GENÉTICA) FENOTIPO FATOR DE NECROSE DE TUMOR Location: BR191.1; 07374/s

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Id: 10183 Author: Kaur, Gurvinder; Sachdeva, Geetanjali; Bhutani, L. K; Bamezai, R Title: Association of polimorphism at COL3A and CTLA4 loci on chromosome 2q31-33 with the clinical phenotype and in-vitro CMI status in healthy and leprosy subjects: a preliminary study ..- Source: s.l; s.n; 1997. 8 p. ilus, tab. Descriptors: HANSENIASE HANSENIASE HANSENIASE DIMORFA HANSENIASE DIMORFA HANSENIASE LEPROMATOSA HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE ALELOS ANTIGENOS DE BACTÉRIAS ANTIGENOS DE DIFERENCIAÇAO CROMOSSOMOS HUMANOS PAR 2 HOMOZIGOTO IMUNIDADE CELULAR TRANSFORMAÇAO LINFOCITICA DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE FENOTIPO REAÇAO EM CADEIA POR POLIMERASE POLIMORFISMO (GENÉTICA) PROCOLAGENO Location: BR191.1; 07096/s

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Id: 10180 Author: Abel, Laurent; Lap, Vu Dinh; Oberti, Jean; Thuc, Nguyen Van; Cua, Van Van; Guilloud-Bataille, Michel; Schurr, Erwin; Lagrange, Philippe H Title: Complex segregation analysis of leprosy in Southern Vietnam ..- Source: s.l; s.n; 1995. 20 p. tab, graf. Descriptors: ADOLESCENCIA CRIANÇA PRÉ-ESCOLAR CHINA SUSCETIBILIDADE A DOENÇA FREQUENCIA DOS GENES HETEROGENEIDADE GENÉTICA LACTENTE RECÉM-NASCIDO HANSENIASE HANSENIASE HANSENIASE MODELOS GENÉTICOS FENOTIPO AMOSTRAGEM VARIAÇAO (GENÉTICA) VIETNA VIETNA Location: BR191.1; 07093/s

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Id: 10073 Author: Blackwell, Jenefer M Title: Genetics of host resistance and susceptibility to intramacrophage pathogens: a study of multicase families of tuberculosis, leprosy and leishmaniasis in north-eastern Brazil ..- Source: s.l; s.n; 1998. 8 p. ilus. Descriptors: HANSENIASE HANSENIASE LEISHMANIOSE LEISHMANIOSE IMUNIDADE NATURAL LIGAÇAO (GENÉTICA) FENOTIPO TUBERCULOSE TUBERCULOSE Location: BR191.1; 07133/s

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Id: 9993 Author: Modlin, Robert L; Bloom, Barry R Title: Immune regulation: learning from leprosy ..- Source: s.l; s.n; 1993. 6 p. ilus, tab. Descriptors: CITOCINAS IMUNIDADE CELULAR HANSENIASE LEPROMATOSA HANSENIASE TUBERCULOIDE HANSENIASE TUBERCULOIDE FENOTIPO LINFOCITOS T Location: BR191.1. 6637/s

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Id: 9961 Author: Schurr, Erwin; Malo, Danielle; Radzioch, Danuta; Buschman, Ellen; Morgan, Kenneth; Gros, Philippe; Skamene, Emil Title: Genetic control of innate resistance to mycobacterial infections ..- Source: s.l; s.n; 1991. 4 p. ilus, graf. Descriptors: MAPEAMENTO CROMOSSOMICO REGULAÇAO DA EXPRESSAO GENICA NO DESENVOLVIMENTO MARCADORES GENÉTICOS IMUNIDADE NATURAL ATIVAÇAO DE MACROFAGOS MACROFAGOS CAMUNDONGOS CAMUNDONGOS CAMUNDONGOS MICOBACTERIOSE MICOBACTERIOSE FENOTIPO TUBERCULOSE TUBERCULOSE Location: BR191.1; 06539/s

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Id: 9819 Author: Feitosa, M; Krieger, H; Borecki, I; Beiguelman, B.; Rao, D. C Title: Genetic epidemiology of the Mitsuda reaction in leprosy ..- Source: s.l; s.n; 1996. 4 p. tab. Descriptors: HANSENIASE DOENÇAS HEREDITARIAS MODELOS GENÉTICOS FENOTIPO Location: BR191.1; 06729/s

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Id: 9816 Author: Soares, D Title: Tibialis posterior transfer for the correction of foot drop in leprosy ..- Source: s.l; s.n; 1996. 2 p. tab. Descriptors: HANSENIASE TENDAO DE AQUILES PÉ PARALISIA PARALISIA RECIDIVA TRANSFERENCIA DE TENDAO MODELOS GENÉTICOS FENOTIPO Location: BR191.1; 06732/s

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Id: 9782 Author: Dessoukey, Mohammed Wagdy; El-Shiemy, Saleh; Sallam, Tarif Title: HLA and leprosy: segregation and linkage study ..- Source: s.l; s.n; 1996. 8 p. tab, graf. Descriptors: HANSENIASE ANTIGENOS HLA HAPLOTIPOS TESTE DE HISTOCOMPATIBILIDADE LIGAÇAO (GENÉTICA) FENOTIPO ALELOS CROMOSSOMOS HUMANOS PAR 6 GENES CLASSE I DO COMPLEXO DE HISTOCOMPATIBILIDADE (MHC) GENOTIPO Location: BR191.1; 06766/s

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Id: 9769 Author: Feitosa, Mary F; Borecki, Ingrid; Krieger, Henrique; Beiguelman, Bernardo Title: The genetic epidemiology of leprosy in a Brazilian population ..- Source: s.l; s.n; 1995. 7 p. tab. Descriptors: HANSENIASE HANSENIASE HANSENIASE BRASIL SUSCETIBILIDADE A DOENÇA GENES RECESSIVOS MORBIDADE FENOTIPO PREVALENCIA FATORES DE RISCO Location: BR191.1; 06779/s

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Id: 9606 Author: Illet, Kenneth F; Chiswell, Gregory M; Spargo, Randolph M; Platt, Elanor; Minchin, Rodney F Title: Acetylation phenotype and genotype in Aboriginal leprosy patients from the north-west region of Western Australia ..- Source: s.l; s.n; 1993. 6 p. tab, graf. Descriptors: ABORIGENES ACETILAÇAO ADOLESCENCIA AUSTRALIA RAÇA AUSTRALOIDE DAPSONA DAPSONA GENOTIPO HANSENIASE HANSENIASE FENOTIPO POLIMORFISMO (GENÉTICA) ARILAMINA N-ACETILTRANSFERASE/*GE/*ME Location: BR191.1; 06586/s

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Id: 9415 Author: Uyemura, Koichi; Ho, Christopher T; Ohmen, Jeffrey D; Rea, Thomas H; Modlin, Robert L Title: Selective expansion of VS1 + T cells from leprosy skin lesions ..- Source: s.l; s.n; 1992. 5 p. ilus, tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS VACINAS BACTERIANAS SEQUENCIA DE BASES LINHAGEM CELULAR REORDENAMENTO GENICO DO LINFOCITO T TESTES INTRADÉRMICOS HANSENIASE TUBERCULOIDE DADOS DE SEQUENCIA MOLECULAR MYCOBACTERIUM LEPRAE - FENOTIPO  RECEPTORES DE ANTIGENO DA CÉLULA-T  RECEPTORES DE ANTIGENO DA CÉLULA-T  PELE  LINFOCITOS T Location: BR191.1; 06387/s

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Id: 8947 Author: Silva, Eliane Aparecida; Rubio, Eliana M; Ura, Somei. Title: Pesquisa de antigenos ABH em eritrocitos e na saliva de pacientes hansenianos / ABH antigens research in erythrocytes and at leprosy patients saliva Source: Hansen. Int;22(2):44-49, jul. - dez. 1997. tab. Abstract: Os poucos estudos já publicados sobre a determinaçäo de fenótipo secretor dos antígenos ABH na saliva de hansenianos têm demonstrado näo haver uma correlaçäo significativa entre estas substâncias e a suscetibilidade à doença. No presente estudo avaliamos 74 pacientes, sendo 27 virchovianos, 23 tuberculóides e 24 dimorfos, quanto à presença de antíngenos ABH nos eritrócitos e na saliva, pela reaçäo de aglutinaçäo em tubo e inibiçäo de aglutinaçäo. A frequência dos grupos sanguineos ABO e do fenótipo secretor e näo secretor nestes pacientes e no grupo controle foram: O= 40,5(por cento) 49(por cento); AB= 6,8(por cento) 3,6(por cento) e näo secretor= 31,1(por cento) 17,5(por cento). Analisando-se os resultados apresentados nos hansenianos, observamos que näo houve antígenos ABH pesquisados nos eritrócitos e na saliva. Descriptors: ANTÍGENOS/análise ANTÍGENOS/imunologia HANSENÍASE/imunologia FENÓTIPO Limits: RELATO DE CASOS HUMANO MASCULINO FEMININO Electronic Medium: http://hansen.bvs.ilsl.br/textoc/hansenint/v21aov29/1997/PDF/v22n2/v22n2a06.pdf / pt Location: BR191.1

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Id: 7960 Author: Souza, Cacilda da Silva Title: Efeito da proteína C-reativa sobre a linfoproliferaçao e fenótipo celular nas formas polares e reacionais da hanseníase ?- Source: Ribeirao Preto; s.n; 1999. 86 p. ilus, tab, graf. Thesis: Present for Universidade de Sao Paulo. Faculdade de Medicina de Ribeirao Preto presented for the degree Doutor. Abstract: Considerando-se que a hanseníase pode ser associada com distintos padroes de resposta imunológica, foram investigados 51 indivíduos; 36 doentes, subdivididos em 12 lepromatosos, 12 tuberculóides e 12 reacionais, e 15 controles normais. A partir de separaçao de células mononucleares do sangue periférico dos indivíduos dos diferentes grupos de estudo, foi realizado o teste de linfoproliferaçao, por 72 horas, com mitógenos policlonais, fitohemaglutinina (PHA) e concavanalina-A (ConA), e com proteína C-reativa (CRP), paralelamente ao estudo de fenótipo das células em cultura. A resposta linfoproliferativa foi medida por incorporaçao de timidina, a quantificaçao das porcentagens de células CD4 e CD8 foi obtida por citometria de fluxo(AU). Descriptors: HANSENIASE FENOTIPO PROTEINA C-REATIVA Location: BR191.1; WC335.502, S89e

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