Database : HANSEN Search on : CELULAS DE SCHWANN/MICROBIOL [Subject descriptor] References found : 16 [refine] Displaying: 1 .. 16   in format [Detailed]

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Id: 18216 Author: Alves, Lucineia; Lima , Leila de Mendonca; Maeda, Elisa da Silva; Carvalho, Lais; Holy, Jon; Sarno, Euzenir Nunes; Pessolani, Maria Cristina Vidal; Barker, Lucia P Title: Mycobacterium lepre infection of human Schwann cells depends on selective host kinases and pathogen-modulated endocytic pathways ..- Source: s.l; s.n; 2004. 9 p. ilus, graf. Abstract: Mycobacterium leprae, an obligate intracellular pathogen, shows a unique tropism for Schwann cells (SC). This leads to the peripheral neuropathy disorde observed in leprosy. In this study, we investigated signal transduction events and the intracellular fate of M. leprae during the interaction of the microorganism with SC. First, we demonstrated that the human schannoma cell line ST88-14 readily phagocytized the bacteria as observed by time-lapse microscopy, actin staining and electron microscopy. The effect of specific kinase inhibitors on M. leprae internalization was then investigated showing that functional protein tyrosine kinase, calcium-dependent protein kinase and phosphatidylinositol 3-kinase, but not cAMP-dependent protein kinase are essential for phagocytosis of the bacteria. Similar results were obtained when irradiated and live bacteria were compared and when M. leprae was pre-coated with recombinant histone-like protein/laminin binding protein, a bacterial adhesion. In a addition, experiments were perfomed to analyze the bacterial trafficking within the endosomal network by labeling the acidified intracellular compartments of M. leprae-infected SC with the Lysotracker acidotrophic probe. Acidification of vesicles containing live M. leprae was minimal in both RAW murine macrophages and SC, although phagosomes containing heat-killed bacteria seem to follow normal endocytic maturation. These data indicate that the invading bacteria interfere with normal endocytic pathway maturation of bacteria-containing phagosomes within SC (AU). Descriptors: MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM LEPRAE/patogen CELULAS DE SCHWANN/microbiol - HANSENIASE/imunol  HANSENIASE/microbiol Limits: HUMANO ANIMAL Location: BR191.1. 9199/s

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Id: 13790 Author: Hagge, Deanna A; Robinson, Sandra Oby; Scollard, David; McCormick, Gregory; Williams, Diana L Title: A new model for studyng the effects of Mycobacterium leprae on Schwann cell and neuron interactions ..- Source: s.l; s.n; 2002. 14 p. ilus, tab. Abstract: Millions of patients with leprosy suffer from nerve damage resulting in disabilities as a consequence of Mycobacterium leprae infection. However, mechanisms of nerve damage have not been elucidated because of the lack of a model that maintains M. leprae viability and mimics disease conditions. A model was developed using viable M. leprae, rat Schwann cells, and Schwann cell-neuron cocultures incubated at 33 degrees C. M. leprae retained 56 per cente viability in Schwann cells for 3 weeks after infection at 33 degrees C, compared with 3.6 per cente viability at 37 degrees C. Infected Schwann cells had altered morphology and expression of genes encoding cellular adhesion molecules at 33 degrees C but were capable of interacting with and myelinating neurons. Cocultures, infected after myelination occurred, showed no morphological changes in myelin architecture after 1 month of incubation at 33 degrees C, and M. leprae retained 53 per cente viability. This article describes a new model for studying the effects of M. leprae on Schwann cells. (AU). Descriptors: CAMUNDONGOS NUS HANSENIASE/microbiol HANSENIASE/patol MODELOS NEUROLOGICOS MICROSCOPIA ELETRÔNICA DE VARREDURA CELULAS CULTIVADAS NEURÔNIOS/microbiol NEURÔNIOS/patol NEURÔNIOS/fisiol COMUNICACAO CELULAR/fisiol MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/fisiol CELULAS DE SCHWANN/microbiol CELULAS DE SCHWANN/patol CELULAS DE SCHWANN/fisiol CELULAS DE SCHWANN/ultraest Limits: HUMANO ANIMAL CAMUNDONGOS RATOS SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09030/s

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Id: 13530 Author: Hagge, Deanna; Robinson, Sandra Oby; Scollard, David; McCormick, Gregory; Williams, Diana L Title: A new model for studying the effects of Mycobacterium leprae on Schwann cell and neuron interactions ..- Source: s.l; s.n; 2002. 4 p. tab. Abstract: Millions of patients with leprosy suffer from nerve damage resulting in disabilities as a consequence of Mycobacterium leprae infection. However, mechanisms of nerve damage have not been elucidated because of the lack of a model that maintains M. leprae viability and mimics disease conditions. A model was developed using viable M. leprae, rat Schwann cells, and Schwann cell-neuron cocultures incubated at 33 degrees C. M. leprae retained 56% viability in Schwann cells for 3 weeks after infection at 33 degrees C, compared with 3.6% viability at 37 degrees C. Infected Schwann cells had altered morphology and expression of genes encoding cellular adhesion molecules at 33 degrees C but were capable of interacting with and myelinating neurons. Cocultures, infected after myelination occurred, showed no morphological changes in myelin architecture after 1 month of incubation at 33 degrees C, and M. leprae retained 53% viability. This article describes a new model for studying the effects of M. leprae on Schwann cells. (AU). Descriptors: COMUNICACAO CELULAR/fisiol CELULAS CULTIVADAS HANSENIASE/microbiol HANSENIASE/patol CAMUNDONGOS NUS MODELOS NEUROLOGICOS NEURÔNIOS/microbiol NEURÔNIOS/patol NEURÔNIOS/fisiol CELULAS DE SCHWANN/microbiol CELULAS DE SCHWANN/patol CELULAS DE SCHWANN/fisiol CELULAS DE SCHWANN/ultraest MICROSCOPIA ELETRÔNICA DE VARREDURA MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/fisiol Limits: ANIMAL HUMANO CAMUNDONGOS RATOS SUPPORT, NON-U.S. GOV'T Location: BR191.1; 08982/s

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Id: 12312 Author: Brophy, Peter J Title: Subversion of Schwann cells and the leper's bell ..- Source: s.l; s.n; May 2002. 2 p. ilus. Descriptors: AXONIOS MORTE CELULAR DIFERENCIAÇAO CELULAR MEMBRANA CELULAR COCULTURA PROTEINAS CITOESQUELETO DOENÇAS DESMIELINIZANTES DISTROFINA GLICOLIPIDIOS LAMININA HANSENIASE HANSENIASE HANSENIASE GLICOPROTEINAS DE MEMBRANAS PROTEINAS DA MEMBRANA CAMUNDONGOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE BAINHA DE MIELINA CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN Limits: ANIMAL Location: BR191.1; 08621/s

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Id: 12289 Author: Sarno, Euzenir Nunes; Pessolani, Maria Cristina Vidal Title: Oldest and most feared disease ..- Source: s.l; s.n; Dec. 2000. 1 p. ilus. Descriptors: DOENÇAS DESMIELINIZANTES HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN FATOR DE NECROSE TUMORAL/PH Location: BR191.1; 08656/s

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Id: 12244 Author: Rambukkana, Anura; Zanazzi, George; Tapinos, Nikos; Salzer, James L Title: Contact-dependent demyelination by mycobacterium leprae in the absence of immune cells ..- Source: s.l; s.n; May 2002. 5 p. ilus, graf. Descriptors: APOPTOSE AXONIOS AXONIOS LINFOCITOS B ADERENCIA BACTERIANA DIVISAO CELULAR COCULTURA DOENÇAS DESMIELINIZANTES GANGLIOS ESPINHAIS GENES RAG-1 GLICOLIPIDIOS HANSENIASE HANSENIASE HANSENIASE HANSENIASE MACROFAGOS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS C57BL CAMUNDONGOS KNOCKOUT MUTAÇAO MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE BAINHA DE MIELINA BAINHA DE MIELINA DEGENERAÇAO NEURAL FIBRAS NERVOSAS MIELINIZADAS NEURONIOS CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN NERVO CIATICO NERVO CIATICO LINFOCITOS T CULTURA DE TECIDO Limits: ANIMAL Location: BR191.1; 08647/s

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Id: 12197 Author: Young, Douglas B Title: Leprosy lipid provides the key to SChwann cell entry ..- Source: s.l; s.n; feb. 2001. 3 p. . Descriptors: GLICOLIPIDIOS HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE CÉLULAS DE SCHWANN Limits: ANIMAL Location: BR191.1; 08704/s

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Id: 12126 Author: Rambukkana, Anura Title: Molecular basis for the peripheral nerve predilection of mycobacterium leprae ..- Source: s.l; s.n; 2001. 7 p. ilus. Descriptors: ANTIGENOS DE BACTÉRIAS PAREDE CELULAR GLICOLIPIDIOS LAMININA HANSENIASE HANSENIASE GLICOPROTEINAS DE MEMBRANAS MODELOS BIOLOGICOS MYCOBACTERIUM LEPRAE NERVOS PERIFÉRICOS LIGAÇAO PROTÉICA CÉLULAS DE SCHWANN TROPISMO Location: BR191.1; 08702/s

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Id: 11945 Author: Lockwood, Diana N. J; Colston, M. J; Khanolkar-Young, S. R Title: The detection of Mycobacterium leprae protein and carbohydrate antigens in skin and nerve from leprosy patients with type 1 (reversal) reactions ..- Source: s.l; s.n; 2002. 7 p. ilus, tab. Descriptors: HANSENIASE DIMORFA HANSENIASE DIMORFA MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE ANTICORPOS ANTIBACTÉRIAS ANTICORPOS MONOCLONAIS ANTIGENOS DE BACTÉRIAS BIOPSIA CHAPERONINAS CHAPERONINAS HIPERSENSIBILIDADE TARDIA IMUNOHISTOQUIMICA LIPOPOLISSACARIDIOS LIPOPOLISSACARIDIOS MACROFAGOS NERVOS PERIFÉRICOS NERVOS PERIFÉRICOS CÉLULAS DE SCHWANN PELE PELE Location: BR191.1; 08600/s

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Id: 11890 Author: Ottenhoff, Tom H. M Title: Mycobacterium leprae and demyelination ..- Source: s.l; s.n; 2002. 2 p. . Descriptors: HANSENIASE HANSENIASE HANSENIASE DOENÇAS DESMIELINIZANTES DOENÇAS DESMIELINIZANTES DOENÇAS DESMIELINIZANTES MYCOBACTERIUM LEPRAE CÉLULAS DE SCHWANN Location: BR191.1; 08572/s

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Id: 11749 Author: Rambukkana, Amura; Zanazzi, George; Tapinos, Nikos; Salzer, James L Title: Contact-dependent demyelination by Mycobacterium leprae in the absence of immune cells ..- Source: s.l; s.n; 2002. 5 p. ilus. Descriptors: HANSENIASE HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE AXONIOS AXONIOS ADERENCIA BACTERIANA DIVISAO CELULAR COCULTURA DOENÇAS DESMIELINIZANTES GANGLIOS ESPINHAIS GENES RAG-1 GLICOLIPIDIOS MACROFAGOS MUTAÇAO BAINHA DE MIELINA BAINHA DE MIELINA DEGENERAÇAO NEURAL - FIBRAS NERVOSAS MIELINIZADAS  NEURONIOS  CÉLULAS DE SCHWANN  CÉLULAS DE SCHWANN  NERVO CIATICO  NERVO CIATICO  LINFOCITOS T  CULTURA DE TECIDO Location: BR191.1; 08525/s

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Id: 11744 Author: Brophy, Peter J Title: Subversion of Schwann cells and the leper's Bell ..- Source: s.l; s.n; 2002. 2 p. ilus. Descriptors: HANSENIASE HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE AXONIOS DIFERENCIAÇAO CELULAR MEMBRANA CELULAR COCULTURA PROTEINAS CITOESQUELETO DOENÇAS DESMIELINIZANTES DISTROFINA GLICOLIPIDIOS LAMININA GLICOPROTEINAS DE MEMBRANAS BAINHA DE MIELINA CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN Location: BR191.1; 08527/s

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Id: 11605 Author: Young, Douglas B Title: Leprosy lipid provides the key to Schwann cell entry ..- Source: s.l; s.n; 2001. 3 p. . Descriptors: HANSENIASE GLICOLIPIDIOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE CÉLULAS DE SCHWANN Location: BR191.1; 08428/s

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Id: 10270 Author: Singh, Neeta; Birdi, Tannaz J; Antia, Noshir H Title: Differential in vitro modulation of schwann cell proliferation by mycobacterium leprae and macrophages in the murine strains, Swiss white and C57BI/6 ..- Source: s.l; s.n; 1998. 10 p. tab, graf. Descriptors: DIVISAO CELULAR COCULTURA HANSENIASE MACROFAGOS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS C57BL MYCOBACTERIUM LEPRAE CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN CELULAS CULTIVADAS Limits: ANIMAL Location: BR191.1; 07165/s

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Id: 10034 Author: Spear, Patricia G Title: A welcome mat for leprosy and Lassa fever ..- Source: s.l; s.n; 1998. 2 p. ilus. Descriptors: HANSENIASE ADERENCIA BACTERIANA PROTEINAS CITOESQUELETO PROTEINAS CITOESQUELETO LAMININA FEBRE LASSA VIRUS LASSA GLICOPROTEINAS DE MEMBRANAS GLICOPROTEINAS DE MEMBRANAS MODELOS BIOLOGICOS MYCOBACTERIUM LEPRAE RECEPTORES VIRAIS CÉLULAS DE SCHWANN Location: BR191.1; 06999/s

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Id: 3840 Author: Job, C. K; Verghese, Roy Title: Schwann cell changes in lepromatous leprosy - electronmicroscope study ..- Source: s.l; s.n; 1975. 4 p. ilus. Descriptors: HANSENIASE HANSENIASE MYCOBACTERIUM LEPRAE CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN Location: BR191.1; 02680/s

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